Cellular Origins and Thrombogenic Activity of Microparticles Isolated From Human Atherosclerotic Plaques

• Published in: Journal of the American College of Cardiology Vol. 49; no. 7; pp. 772 - 777
• Main Authors: Leroyer, Aurélie S., BSc, Isobe, Hirotaka, PhD, Lesèche, Guy, MD, PhD, Castier, Yves, MD, PhD, Wassef, Michel, PhD, Mallat, Ziad, MD, PhD, Binder, Bernd R., MD, PhD, Tedgui, Alain, PhD, Boulanger, Chantal M., PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 20-02-2007; Elsevier Science; Elsevier Limited
• Subjects: Aged; Apoptosis; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Blood platelets; Cardiology; Cardiology. Vascular system; Cardiovascular; Carotid Stenosis - blood; Carotid Stenosis - pathology; Carotid Stenosis - surgery; Endarterectomy, Carotid; Female; Humans; Internal Medicine; Leukocytes - metabolism; Leukocytes - pathology; Lymphocytes; Male; Medical sciences; Microscopy; Muscular system; Plasma; Smooth muscle; Thrombin - metabolism; United States > US; California; smooth muscle cell actin; immunoglobulin G; smooth muscle cell; tissue factor; SMA; IgG; SMC; microparticles; thrombin-generating activity; red blood cell; TGA; MPs; RBC; TF; PFP; platelet-free plasma; Vascular disease; Human; Origin; Atherosclerotic plaque; Atherosclerosis; Cardiovascular disease; Activity; Circulatory system; Cardiology; Cell; Phlebology
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2006.10.053

Cellular Origins and Thrombogenic Activity of Microparticles Isolated From Human Atherosclerotic Plaques Aurélie S. Leroyer, Hirotaka Isobe, Guy Leséche, Yves Castier, Michel Wassef, Ziad Mallat, Bernd R. Binder, Alain Tedgui, Chantal M. Boulanger Atherosclerotic plaques contain submicron microparticles released during cell activation or apoptosis. Plaque microparticles originate mainly from macrophages, erythrocytes, and smooth muscle cells, contrasting with plasma microparticles, which are primarily derived from platelets and show no smooth muscle cell origin. The different cellular origins of plaque and plasma microparticles may explain increased thrombogenic activity of plaque microparticles.