Biometry of the corpus callosum assessed by 3D ultrasound and its correlation to neurodevelopmental outcome in very low birth weight infants

• Published in: Journal of perinatology Vol. 37; no. 4; pp. 448 - 453
• Main Authors: Klebermass-Schrehof, K, Aumüller, S, Goeral, K, Vergesslich-Rothschild, K, Fuiko, R, Brandstetter, S, Berger, A, Jilma, B, Haiden, N
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01-04-2017; Nature Publishing Group
• Subjects: 631/136; Age; Analysis; Austria; Biometrics; Biometry; Birth weight; Birth weight, Low; Child Development; Child, Preschool; Corpus callosum; Corpus Callosum - diagnostic imaging; Diagnosis; Female; Gestational Age; Growth; Humans; Imaging, Three-Dimensional; Infant; Infant, Newborn; Infant, Premature - growth & development; Infant, Very Low Birth Weight - growth & development; Infants; Intensive care; Low birth weight; Male; Medical examination; Medicine; Medicine & Public Health; Methods; Neonatal care; Neonates; Neurodevelopment; Newborn babies; original-article; Patient outcomes; Pediatric neurology; Pediatric Surgery; Pediatrics; Physiological aspects; Premature babies; Premature infants; Prospective Studies; Reference Values; Ultrasonic diagnostic equipment; Ultrasonic imaging; Ultrasonography; Ultrasound; Austria; United States > US
• ISSN: 0743-8346; 1476-5543
• DOI: 10.1038/jp.2016.231

Objective:
Several studies have shown a relation between the size of corpus callosum (CC) and outcome in preterm infants. Three-dimensional ultrasound (3D-US) offers new perspectives in cerebral imaging. To establish reference values for biometry of the CC in very low birth weight infants and to correlate these measurements to neurodevelopmental outcome at 5 years of age.
Study Design:
Forty-three preterm infants with a gestational age <32 weeks were included. Transfontanellar 3D-US measurements were obtained at nine different timepoints.
Results:
3D-US-based reference values for size, length, circumference and surface area of the CC could be established. Measurements at term-equivalent age showed a correlation to neurodevelopment outcome.
Conclusion:
Reliable biometric data of the CC can be established in preterm infants by 3D-US and correlate with neurodevelopmental outcome.