Studying the antibody repertoire after vaccination: practical applications

Highlights • Next-generation sequencing allows in-depth characterization of antibody repertoires. • Vaccination can be used as a model system to study changes in antibody repertoire. • Repertoire analysis provides insight into mechanisms underlying protective immunity. • Repertoire sequencing could...

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Bibliographic Details
Published in:	Trends in immunology Vol. 35; no. 7; pp. 319 - 331
Main Authors:	Galson, Jacob D, Pollard, Andrew J, Trück, Johannes, Kelly, Dominic F
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-07-2014 Elsevier Limited
Subjects:	Allergy and Immunology Animals Antibody Formation - genetics antibody repertoire Antigens B cell receptor repertoire B-Lymphocytes - immunology Drug Discovery Genes, Immunoglobulin - genetics High-Throughput Nucleotide Sequencing Humans Immunity, Active Immunization immunoglobulin repertoire next generation sequencing Studies Vaccination Vaccines Vaccines - immunology VDJ B cell receptor repertoire VDJ immunoglobulin repertoire next generation sequencing antibody repertoire vaccination
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Summary:	Highlights • Next-generation sequencing allows in-depth characterization of antibody repertoires. • Vaccination can be used as a model system to study changes in antibody repertoire. • Repertoire analysis provides insight into mechanisms underlying protective immunity. • Repertoire sequencing could be used as a novel measure of vaccine immunogenicity.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1471-4906 1471-4981
DOI:	10.1016/j.it.2014.04.005