Outcome of Renal Transplantation in Patients With Type 2 Diabetic Nephropathy: A Single-Center Experience

• Published in: Transplantation proceedings Vol. 47; no. 3; pp. 608 - 611
• Main Authors: Noguchi, H, Kitada, H, Kaku, K, Kurihara, K, Kawanami, S, Tsuchimoto, A, Masutani, K, Nakamura, U, Tanaka, M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-04-2015
• Subjects: Adult; Aged; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Diabetes Mellitus, Type 2 - complications; Diabetic Nephropathies - surgery; Female; Graft Survival; Humans; Incidence; Kidney Failure, Chronic - surgery; Kidney Transplantation - adverse effects; Kidney Transplantation - mortality; Living Donors; Male; Middle Aged; Renal Dialysis - adverse effects; Retrospective Studies; Surgery; Survival Rate
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2014.12.047

Abstract Background Renal transplantation has been established as a treatment for end-stage renal disease (ESRD) due to diabetic nephropathy. However, few studies have focused on the outcome after renal transplantation in patients with ESRD and type 2 diabetic nephropathy. To investigate the effect of renal transplantation on ESRD with type 2 diabetic nephropathy, we retrospectively analyzed patients who received renal transplantation at our facility. This study aimed to compare the outcome of renal transplantation for type 2 diabetic nephropathy with that for nondiabetic nephropathy. Methods We studied 290 adult patients, including 65 with type 2 diabetic nephropathy (DM group) and 225 with nondiabetic nephropathy (NDM group), who underwent living-donor renal transplantation at our facility from February 2008 to March 2013. We compared the 2 groups retrospectively. Results In the DM and NDM groups, the 5-year patient survival rates were 96.6% and 98.7%, and the 5-year graft survival rates were 96.8% and 98.0%, respectively, with no significant differences between the groups. There were no significant differences in the rates of surgical complications, rejection, and infection. The cumulative incidence of postoperative cardiovascular events was higher in the DM group than in the NDM group (8.5% vs 0.49% at 5 years; P  = .002). Conclusions Patient and graft survival rates after renal transplantation for type 2 diabetic nephropathy are not inferior to those for recipients without diabetic nephropathy. Considering the poor prognosis of patients with diabetic nephropathy on dialysis, renal transplantation can provide significant benefits for these patients.