Cell-to-cell spread of HIV-1 and evasion of neutralizing antibodies

• Published in: Vaccine Vol. 31; no. 49; pp. 5789 - 5797
• Main Authors: Schiffner, Torben, Sattentau, Quentin J, Duncan, Christopher J.A
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 02-12-2013; Elsevier; Elsevier Limited
• Subjects: Allergy and Immunology; Antibodies, Neutralizing - immunology; Antigens; Applied microbiology; Biological and medical sciences; Broadly neutralizing; CD4-binding site; Dendritic cell; Dendritic Cells - immunology; env Gene Products, Human Immunodeficiency Virus - immunology; Envelope; Epitopes - immunology; Fundamental and applied biological sciences. Psychology; HIV; HIV Antibodies - immunology; HIV Infections - immunology; HIV-1 - immunology; HIV-1 - physiology; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Immune Evasion; Immunization; Immunological Synapses - virology; Infections; Infectious synapse; Lymphocytes; Macrophage; Microbiology; Miscellaneous; Mutation; T cell; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Virological synapse; Virology; Virological synapse; Dendritic cell; Broadly neutralizing; Infectious synapse; T cell; CD4-binding site; Envelope; Macrophage; HIV-1 virus; Retroviridae; Binding site; Lentivirus; Neutralizing antibody; Virus; Synapse; T-Lymphocyte; Human immunodeficiency virus
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2013.10.020

Highlights • Induction of HIV-1 envelope glycoprotein (Env) directed broadly neutralizing antibodies (bNAbs) is a potential vaccine strategy. • Cell-to-cell transmission of HIV-1 at immune cell synapses is a highly efficient method of HIV-1 dissemination. • Infection at synapses is dependent upon receptor engagement and Env-mediated fusion and thus is amenable to bNAb inhibition. • Epitope-specific reduction in neutralization activity compared to cell-free inhibition has been reported. • The mechanisms governing the relative restriction in neutralization activity in cell-to-cell transmission are unknown.