Lamivudine-based two-drug regimens with dolutegravir or protease inhibitor: Virological suppression in spite of previous therapy failure or renal dysfunction

• Published in: The Brazilian journal of infectious diseases Vol. 27; no. 3; p. 102757
• Main Authors: Matsuda, Elaine Monteiro, Campos, Ivana Barros, de Oliveira, Isabela Penteriche, Colpas, Daniela Rodrigues, López-Lopes, Giselle Ibete Silva, Chiavegato, Victor Oliveira, Brígido, Luís Fernando de Macedo
• Format: Journal Article
• Language: English
• Published: Brazil Elsevier España, S.L.U 01-05-2023; Contexto; Elsevier; Brazilian Society of Infectious Diseases
• Subjects: 2DR; 3TC resistance; CKD-EPI; Complications and side effects; Dual therapy; Highly active antiretroviral therapy; HIV-1; INFECTIOUS DISEASES; Lamivudine; Original; Patient outcomes; Brazil; HIV-1; 2DR; Dual therapy; CKD-EPI; 3TC resistance
• ISSN: 1413-8670; 1678-4391; 1678-4391
• DOI: 10.1016/j.bjid.2023.102757

Two-Drug Regimens (2DR) have proven effective in clinical trials but real-world data, especially in resource-limited settings, is limited.
To evaluate viral suppression of lamivudine-based 2DR, with dolutegravir or ritonavir-boosted protease inhibitor (lopinavir/r, atazanavir/r or darunavir/r), among all cases regardless of selection criteria.
A retrospective study, conducted in an HIV clinic in the metropolitan area of São Paulo, Brazil. Per-protocol failure was defined as viremia above 200 copies/mL at outcome. Intention-To-Treat-Exposed (ITT-E) failure was considered for those who initiated 2DR but subsequently had either (i) Delay over 30 days in Antiretroviral Treatment (ART) dispensation, (ii) ART changed or (iii) Viremia > 200 copies/mL in the last observation using 2DR.
Out of 278 patients initiating 2DR, 99.6% had viremia below 200 copies/mL at last observation, 97.8% below 50 copies/mL. Lamivudine resistance, either documented (M184V) or presumed (viremia > 200 copies/mL over a month using 3TC) was present in 11% of cases that showed lower suppression rates (97%), but with no significant hazard ratio to fail per ITT-E (1.24, p = 0.78). Decreased kidney function, present in 18 cases, showed of 4.69 hazard ratio (p = 0.02) per ITT-E for failure (3/18). As per protocol analysis, three failures occurred, none with renal dysfunction.
The 2DR is feasible, with robust suppression rates, even when 3TC resistance or renal dysfunction is present, and close monitoring of these cases may guarantee long-term suppression.