Systematic review and meta-analysis of community and facility-based HIV testing to address linkage to care gaps in sub-Saharan Africa

• Published in: Nature (London) Vol. 528; no. 7580; pp. S77 - S85
• Main Authors: Sharma, Monisha, Ying, Roger, Tarr, Gillian, Barnabas, Ruanne
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03-12-2015; Nature Publishing Group
• Subjects: 631/154/140; 692/699/255; 692/699/255/1629; Africa South of the Sahara; Analysis; Antiretroviral agents; Care and treatment; CD4 Lymphocyte Count; Complications and side effects; Costs; Counseling; Diagnostic Tests, Routine - economics; Diagnostic Tests, Routine - utilization; Epidemics; Health aspects; Health care delivery; Health Services Needs and Demand - economics; HIV; HIV infections; HIV Infections - diagnosis; HIV Infections - drug therapy; HIV Infections - economics; HIV Infections - virology; Human immunodeficiency virus; Humanities and Social Sciences; Humans; Intervention; Mathematical models; Medical tests; Meta-analysis; multidisciplinary; Prevention; Science; Sex Distribution; Sexually transmitted diseases; STD; Studies; supplement; Systematic review; Viral Load - drug effects; Young adults; Africa South of the Sahara; Sub-Saharan Africa
• ISSN: 0028-0836; 1476-4687
• DOI: 10.1038/nature16044

HIV testing and counselling is the first crucial step for linkage to HIV treatment and prevention. However, despite high HIV burden in sub-Saharan Africa, testing coverage is low, particularly among young adults and men. Community-based HIV testing and counselling (testing outside of health facilities) has the potential to reduce coverage gaps, but the relative impact of different modalities is not well assessed. We conducted a systematic review of HIV testing modalities, characterizing community (home, mobile, index, key populations, campaign, workplace and self-testing) and facility approaches by population reached, HIV positivity, CD4 count at diagnosis and linkage. Of 2,520 abstracts screened, 126 met eligibility criteria. Community HIV testing and counselling had high coverage and uptake and identified HIV-positive people at higher CD4 counts than facility testing. Mobile HIV testing reached the highest proportion of men of all modalities examined (50%, 95% confidence interval (CI) = 47–54%) and home with self-testing reached the highest proportion of young adults (66%, 95% CI = 65–67%). Few studies evaluated HIV testing for key populations (commercial sex workers and men who have sex with men), but these interventions yielded high HIV positivity (38%, 95% CI = 19–62%) combined with the highest proportion of first-time testers (78%, 95% CI = 63–88%), indicating service gaps. Community testing with facilitated linkage (for example, counsellor follow-up to support linkage) achieved high linkage to care (95%, 95% CI = 87–98%) and antiretroviral initiation (75%, 95% CI = 68–82%). Expanding home and mobile testing, self-testing and outreach to key populations with facilitated linkage can increase the proportion of men, young adults and high-risk individuals linked to HIV treatment and prevention, and decrease HIV burden.
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