Morphine Analgesia Potentiated but Tolerance not Affected by Active Immunization against Cholecystokinin

• Published in: Science (American Association for the Advancement of Science) Vol. 226; no. 4679; pp. 1215 - 1217
• Main Authors: Faris, Patricia L., McLaughlin, Carol L., Baile, Clifton A., Olney, John W., Komisaruk, Barry R.
• Format: Journal Article
• Language: English
• Published: Washington, DC The American Association for the Advancement of Science 07-12-1984; American Association for the Advancement of Science
• Subjects: Analgesia; Analgesics; Animals; Antibodies; Biological and medical sciences; Cholecystokinin; Cholecystokinin - immunology; Cholecystokinin - physiology; Cholecystokinin receptors; Drug Tolerance; Immunization; Male; Medical sciences; Morphine; Morphine - pharmacology; Neuropharmacology; Opiates; Pain; Pain - physiology; Pharmacological research; Pharmacology, Experimental; Pharmacology. Drug treatments; Physiological aspects; Prevention; Rats; Rats, Inbred Strains; Subcutaneous injections; Time Factors; Tolerance; Analgesia; Cholecystokinin
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.6505689

Administration of cholecystokinin was recently found to attenuate opiate analgesia. In the present study, the role of endogenous cholecystokinin in opiate analgesia was examined. Endogenously released cholecystokinin was sequestered by antibodies to cholecystokinin developed in response to an active immunization procedure. Morphine analgesia was potentiated and prolonged in rats immunized against cholecystokinin. The rate of development of morphine tolerance, however, was not affected by the antibodies. Endogenous cholecystokinin appears to function as a short-term modulator of opiate action.