Gut microbiota and autism spectrum disorders: where do we stand?

• Published in: Gut pathogens Vol. 15; no. 1; pp. 1 - 50
• Main Authors: Zyoud, Sa'ed H, Shakhshir, Muna, Abushanab, Amani S, Koni, Amer, Shahwan, Moyad, Jairoun, Ammar A, Abu Taha, Adham, Al-Jabi, Samah W
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 25-10-2023; BioMed Central; BMC
• Subjects: Analysis; ASD; Author productivity; Autism; Autism spectrum disorders; Bibliometric; Bibliometrics; Brain research; Children; Citation analysis; Citation indexes; Collaboration; Digestive system; E coli; Feces; Funding; Gastrointestinal tract; Gut microbiota; Intestinal microflora; Medical research; Medicine, Experimental; Metabolism; Microbiota; Microbiota (Symbiotic organisms); Probiotics; Publication output; Scopus; Trends; China
• ISSN: 1757-4749; 1757-4749
• DOI: 10.1186/s13099-023-00575-8

Background Children with autism spectrum disorder (ASD) often have digestive problems and microbial imbalances in their guts, suggesting that these conditions may play a role in the development of the disorder. Scopus-based research on the gut microbiota and ASD was examined in this bibliometric analysis to shed light on the current state of research and identify potential hotspots for future work in this area. Methods We searched documents from the Scopus database and reference citation analysis to collect published data on the gut microbiota and ASD from 2003 to 2022. The downloaded document records were exported to VOSviewer v.1.6.19 to examine and visualize the collaboration between countries and determine the research hotspots. Results The search yielded 958 articles specifically dedicated to gut microbiota and ASD. The number of publications in this field increased rapidly after 2013, with a peak in 2022. The United States (n = 267; 27.87%) was the most active country, followed by China (n = 171; 17.85%) and Italy (n = 96; 10.02). International collaboration was observed, with the USA playing a central role. University College Cork, Ireland, was the most productive institution (n = 24; 2.51%). The National Natural Science Foundation of China was the most active funding agency (n = 76; 7.93%). Nutrients journal had the highest number of publications (n = 28; 2.92%). The articles related to gut microbiota and ASD were highly cited, with an h-index of 108. The research themes identified focused on the modulation of gut microbiota as a potential therapy for children with ASD and gut-brain axis dysfunction in ASD. Conclusions In recent years, the study of gut microbiota and its association with ASD has garnered considerable interest as an emergent field of study. The results of this study substantially enhance our current understanding of the knowledge landscape in this field and illuminate potential avenues for future research. It is essential to emphasize the significance of devoting more resources to the newest and most promising research areas, such as investigating the potential therapeutic benefits of modulating the intestinal microbiota in children with ASD. This research has enormous potential and merits intensified focus and investigation. Keywords: ASD, Autism, Gut microbiota, Autism spectrum disorders, Bibliometric, Scopus, Reference citation analysis