Utility and validity of DISC1 mouse models in biological psychiatry

Highlights • Multiple DISC1 models have been generated, but can be organized into three categories. • DISC1 models are useful in their biological and face validities. • DISC1 models are utilized at molecular, cellular, circuitry, and behavioral levels. • Several enigmas in DISC1 biology at present c...

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Bibliographic Details
Published in:	Neuroscience Vol. 321; pp. 99 - 107
Main Authors:	Tomoda, T, Sumitomo, A, Jaaro-Peled, H, Sawa, A
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 03-05-2016
Subjects:	Animals DISC1 Disease Models, Animal Humans Mental Disorders - genetics Mental Disorders - metabolism Mental Disorders - physiopathology Mice, Mutant Strains Mice, Transgenic mouse models Nerve Tissue Proteins - genetics Neurology psychiatry Translational Research, Biomedical mouse models Diagnostic and Statistical Manual of Mental Disorders AD Alzheimer’s disease Disrupted-in-schizophrenia 1 PPI p21-activated kinase DN prepulse inhibition psychiatry dominant-negative PAK DISC1 DSM
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Summary:	Highlights • Multiple DISC1 models have been generated, but can be organized into three categories. • DISC1 models are useful in their biological and face validities. • DISC1 models are utilized at molecular, cellular, circuitry, and behavioral levels. • Several enigmas in DISC1 biology at present can be addressed with the mouse models.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.12.061