Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers

• Published in: Scientific reports Vol. 7; no. 1; pp. 8606 - 6
• Main Authors: Liu, Yang, Maccarini, Paolo, Palmer, Gregory M., Etienne, Wiguins, Zhao, Yulin, Lee, Chen-Ting, Ma, Xiumei, Inman, Brant A., Vo-Dinh, Tuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17-08-2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/31; 631/61/350; 631/67/1059; 64/60; Animals; Bladder cancer; Cancer; Cancer therapies; Chemotherapy; Humanities and Social Sciences; Hyperthermia, Induced; Immune checkpoint inhibitors; Immunophenotyping; Kaplan-Meier Estimate; Metastases; Metastasis; Mice; multidisciplinary; Neoplasm Metastasis; Phototherapy; Science; Science (multidisciplinary); Theranostic Nanomedicine; Tumors; Urinary bladder; Urinary Bladder Neoplasms - immunology; Urinary Bladder Neoplasms - therapy
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-09116-1

Metastatic spread is the mechanism in more than 90 percent of cancer deaths and current therapeutic options, such as systemic chemotherapy, are often ineffective. Here we provide a proof of principle for a novel two-pronged modality referred to as
Sy
nergistic I
m
muno
Pho
tothermal
N
anotherap
y
(SYMPHONY) having the potential to safely eradicate both primary tumors and distant metastatic foci. Using a combination of immune-checkpoint inhibition and plasmonic gold nanostar (GNS)–mediated photothermal therapy, we were able to achieve complete eradication of primary treated tumors and distant untreated tumors in some mice implanted with the MB49 bladder cancer cells. Delayed rechallenge with MB49 cancer cells injection in mice that appeared cured by SYMPHONY did not lead to new tumor formation after 60 days observation, indicating that SYMPHONY treatment induced effective long-lasting immunity against MB49 cancer cells.