Isolation of a bromo analog of rebeccamycin from Saccharothrix aerocolonigenes

When grown in a defined medium containing 0.05% KBr, Saccharothrix aerocolonigenes ATCC 39243 produces a novel bromo analog of rebeccamycin. This new analog, designated bromorebeccamycin, has been isolated from the culture broth and purified by vacuum liquid chromatography and column chromatography....

Full description

Saved in:

Bibliographic Details
Published in:	Journal of antibiotics Vol. 44; no. 9; p. 934
Main Authors:	Lam, K S, Schroeder, D R, Veitch, J M, Matson, J A, Forenza, S
Format:	Journal Article
Language:	English
Published:	Japan 1991
Subjects:	Aminoglycosides Animals Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - therapeutic use Carbazoles Chemical Phenomena Chemistry Chromatography, High Pressure Liquid Indoles Leukemia P388 - drug therapy Mice Saccharomycetales - chemistry
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	When grown in a defined medium containing 0.05% KBr, Saccharothrix aerocolonigenes ATCC 39243 produces a novel bromo analog of rebeccamycin. This new analog, designated bromorebeccamycin, has been isolated from the culture broth and purified by vacuum liquid chromatography and column chromatography. Spectroscopic data demonstrated that bromorebeccamycin has the same structure as rebeccamycin, except for the replacement of the two chlorine atoms by bromine atoms in the molecule. Bromorebeccamycin and rebeccamycin have a similar potency and activity against P388 leukemia in the murine model.
ISSN:	0021-8820
DOI:	10.7164/antibiotics.44.934