Clinical outcomes of primary surgical treatment for acquired vulvar lymphangioma circumscriptum

• Published in: Archives of gynecology and obstetrics Vol. 293; no. 1; pp. 157 - 162
• Main Authors: Yoon, Gun, Kim, Hyun-Soo, Lee, Yoo-Young, Kim, Tae-Joong, Choi, Chel-Hun, Kim, Byoung-Gie, Bae, Duk-Soo, Hwang, Ji Hye, Lee, Jeong-Won
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-01-2016; Springer Nature B.V
• Subjects: Adult; Aged; Cancer therapies; Cervical cancer; Chemoradiotherapy; Clinical outcomes; Combined Modality Therapy; Endocrinology; Female; Gynecologic Oncology; Gynecology; Human Genetics; Humans; Hysterectomy; Lymphangioma - etiology; Lymphangioma - pathology; Lymphangioma - psychology; Lymphangioma - surgery; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Recurrence, Local - therapy; Neoplasms, Radiation-Induced - etiology; Neoplasms, Radiation-Induced - pathology; Neoplasms, Radiation-Induced - surgery; Obstetrics/Perinatology/Midwifery; Patients; Prognosis; Quality of Life; Radiation therapy; Radiotherapy - adverse effects; Retrospective Studies; Surgery; Uterine Cervical Neoplasms - radiotherapy; Uterine Cervical Neoplasms - surgery; Uterine Cervical Neoplasms - therapy; Vulva - pathology; Vulva - surgery; Vulvar Diseases - etiology; Vulvar Diseases - pathology; Vulvar Diseases - surgery; Vulvar Neoplasms - etiology; Vulvar Neoplasms - pathology; Vulvar Neoplasms - psychology; Vulvar Neoplasms - surgery; Vulva; Radiation therapy; Lymphangioma circumscriptum; Radical hysterectomy; Surgery; Cervical cancer
• ISSN: 0932-0067; 1432-0711
• DOI: 10.1007/s00404-015-3801-3

Objective
To assess the clinical outcomes of surgical treatment for acquired vulvar lymphangioma circumscriptum in patients who received radical surgery and/or adjuvant radiation therapy for cervical cancer.
Methods
A retrospective chart review of eight patients was performed to assess the demographic information, chief complaints, treatment modality for cervical cancer, location, and primary treatment modality for vulvar LC, postoperative changes in symptoms, and/or signs, the development of local recurrence and the outcome of patients.
Results
All eight patients were previously diagnosed with cervical cancer FIGO clinical stage IA to IIA and received surgery, radiation therapy, or concurrent chemoradiation therapy. Microscopic examination revealed multiple, dilated, D2-40-positive dermal vascular channels containing eosinophilic proteinaceous material, consistent with LC. Most chief complaints showed considerable improvements on assessment at the outpatient clinic after the primary surgery. No patient showed aggravation of symptoms. Two patients developed local recurrences. One patient developed recurrence on the opposite side 13 months after local excision. We performed a second wide local excision. Another patient developed recurrence 47 months after the primary surgery. Since the lesion was very small and localized, we decided to manage it conservatively, but monitor it very closely. The remaining six patients remained free of recurrence.
Conclusion
It is not easy for gynecologists to have an initial clinical diagnosis of LC, because there are a number of diseases that exhibit similar clinical manifestation to that of vulvar LC. Even if it is diagnosed correctly, local recurrence often occurs. Relevant symptoms associated with LC are not only distressing, but also affect patients’ quality of life. Based on our data, we propose that surgical treatment could provide a more long-lasting answer compared to other treatment modalities, since it is beneficial in terms of clinical outcomes. In the future, a long-term follow-up investigation is required to assess the prognosis and to compare the efficacy and side effects of each modality.