Brain oscillations differentially encode noxious stimulus intensity and pain intensity

• Published in: NeuroImage (Orlando, Fla.) Vol. 148; pp. 141 - 147
• Main Authors: Nickel, Moritz M., May, Elisabeth S., Tiemann, Laura, Schmidt, Paul, Postorino, Martina, Ta Dinh, Son, Gross, Joachim, Ploner, Markus
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-03-2017; Elsevier Limited; Academic Press
• Subjects: Adult; Affect - physiology; Alpha; Alpha Rhythm; Animal behavior; Beta; Beta Rhythm; Brain; Brain - physiopathology; Brain Mapping; Electroencephalography; Female; Functional Laterality - physiology; Gamma; Gamma Rhythm - physiology; Healthy Volunteers; Heat; Hot Temperature; Humans; Male; Nociception; Oscillations; Pain; Pain - physiopathology; Pain - psychology; Physical Stimulation; Prefrontal Cortex - physiopathology; Sensorimotor Cortex - physiopathology; Tonic; Visual task performance; Young Adult; Nociception; Gamma; Pain; Oscillations; Alpha; Tonic; Beta
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2017.01.011

Noxious stimuli induce physiological processes which commonly translate into pain. However, under certain conditions, pain intensity can substantially dissociate from stimulus intensity, e.g. during longer-lasting pain in chronic pain syndromes. How stimulus intensity and pain intensity are differentially represented in the human brain is, however, not yet fully understood. We therefore used electroencephalography (EEG) to investigate the cerebral representation of noxious stimulus intensity and pain intensity during 10min of painful heat stimulation in 39 healthy human participants. Time courses of objective stimulus intensity and subjective pain ratings indicated a dissociation of both measures. EEG data showed that stimulus intensity was encoded by decreases of neuronal oscillations at alpha and beta frequencies in sensorimotor areas. In contrast, pain intensity was encoded by gamma oscillations in the medial prefrontal cortex. Contrasting right versus left hand stimulation revealed that the encoding of stimulus intensity in contralateral sensorimotor areas depended on the stimulation side. In contrast, a conjunction analysis of right and left hand stimulation revealed that the encoding of pain in the medial prefrontal cortex was independent of the side of stimulation. Thus, the translation of noxious stimulus intensity into pain is associated with a change from a spatially specific representation of stimulus intensity by alpha and beta oscillations in sensorimotor areas to a spatially independent representation of pain by gamma oscillations in brain areas related to cognitive and affective-motivational processes. These findings extend the understanding of the brain mechanisms of nociception and pain and their dissociations during longer-lasting pain as a key symptom of chronic pain syndromes.
•Stimulus intensity is encoded by alpha/beta oscillations in sensorimotor areas.•Pain intensity is encoded by gamma oscillations in the medial prefrontal cortex.•The encoding of stimulus intensity depends on stimulation side.•The encoding of pain is independent of stimulation side.