Longitudinal pathways of cerebrospinal fluid and positron emission tomography biomarkers of amyloid-β positivity

Mismatch between CSF and PET amyloid-β biomarkers occurs in up to ≈20% of preclinical/prodromal Alzheimer’s disease individuals. Factors underlying mismatching results remain unclear. In this study we hypothesized that CSF/PET discordance provides unique biological/clinical information. To test this...

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Published in:Molecular psychiatry Vol. 26; no. 10; pp. 5864 - 5874
Main Authors: Sala, Arianna, Nordberg, Agneta, Rodriguez-Vieitez, Elena
Format: Journal Article Web Resource
Language:English
Published: London Nature Publishing Group UK 01-10-2021
Nature Publishing Group
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Summary:Mismatch between CSF and PET amyloid-β biomarkers occurs in up to ≈20% of preclinical/prodromal Alzheimer’s disease individuals. Factors underlying mismatching results remain unclear. In this study we hypothesized that CSF/PET discordance provides unique biological/clinical information. To test this hypothesis, we investigated non-demented and demented participants with CSF amyloid-β 42 and [18F]Florbetapir PET assessments at baseline ( n  = 867) and at 2-year follow-up ( n  = 289). Longitudinal trajectories of amyloid-β positivity were tracked simultaneously for CSF and PET biomarkers. In the longitudinal cohort ( n  = 289), we found that participants with normal CSF/PET amyloid-β biomarkers progressed more frequently toward CSF/PET discordance than to full CSF/PET positivity ( χ 2 (1)  = 5.40; p  < 0.05). Progression to CSF+/PET+ status was ten times more frequent in cases with discordant biomarkers, as compared to csf−/pet− cases ( χ 2 (1)  = 18.86; p  < 0.001). Compared to the CSF+/pet− group, the csf−/PET+ group had lower APOE -ε4ε4 prevalence ( χ 2 (6)  = 197; p  < 0.001; n  = 867) and slower rate of brain amyloid-β accumulation ( F (3,600)  = 12.76; p  < 0.001; n  = 608). These results demonstrate that biomarker discordance is a typical stage in the natural history of amyloid-β accumulation, with CSF or PET becoming abnormal first and not concurrently. Therefore, biomarker discordance allows for identification of individuals with elevated risk of progression toward fully abnormal amyloid-β biomarkers, with subsequent risk of neurodegeneration and cognitive decline. Our results also suggest that there are two alternative pathways (“CSF-first” vs. “PET-first”) toward established amyloid-β pathology, characterized by different genetic profiles and rates of amyloid-β accumulation. In conclusion, CSF and PET amyloid-β biomarkers provide distinct information, with potential implications for their use as biomarkers in clinical trials.
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scopus-id:2-s2.0-85097532229
ISSN:1359-4184
1476-5578
1476-5578
DOI:10.1038/s41380-020-00950-w