Sprint Training Increases Muscle Oxidative Metabolism During High-Intensity Exercise in Patients With Type 1 Diabetes

• Published in: Diabetes care Vol. 31; no. 11; pp. 2097 - 2102
• Main Authors: HARMER, Alison R, CHISHOLM, Donald J, MCKENNA, Michael J, HUNTER, Sandra K, RUELL, Patricia A, NAYLOR, Justine M, MAXWELL, Lyndal J, FLACK, Jeff R
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01-11-2008
• Subjects: Adult; Biological and medical sciences; Blood Glucose - metabolism; Clinical Care/Education/Nutrition/Psychosocial Research; Communications industry; Diabetes; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - metabolism; Diabetes Mellitus, Type 1 - physiopathology; Diabetes therapy; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Enzymes; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Exercise; Exercise - physiology; Exercise Test; Female; Humans; Male; Medical sciences; Metabolic diseases; Metabolism; Metabolites; Miscellaneous; Muscle, Skeletal - metabolism; Oxygen Consumption - physiology; Physiological aspects; Public health. Hygiene; Public health. Hygiene-occupational medicine; Sports training; Telecommunications services industry; Type 1 diabetes; Young Adult; Endocrinopathy; Physical exercise; Human; Immunopathology; High intensity; Nutrition; Patient; Autoimmune disease; Metabolic diseases; Increase; Metabolism; Type 1 diabetes; Muscle; Endocrinology
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/dc08-0329

Sprint Training Increases Muscle Oxidative Metabolism During High-Intensity Exercise in Patients With Type 1 Diabetes
Alison R. Harmer , PHD 1 2 ,
Donald J. Chisholm , MD 3 ,
Michael J. McKenna , PHD 4 ,
Sandra K. Hunter , PHD 2 ,
Patricia A. Ruell , PHD 2 ,
Justine M. Naylor , PHD 1 ,
Lyndal J. Maxwell , PHD 1 and
Jeff R. Flack , MD 5
1 Discipline of Physiotherapy, University of Sydney, Lidcombe, New South Wales, Australia
2 Discipline of Exercise and Sports Science, University of Sydney, Lidcombe, New South Wales, Australia
3 Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
4 School of Human Movement, Recreation, and Performance, Centre for Aging, Rehabilitation, Exercise, and Sport, Victoria University,
Melbourne, Victoria, Australia
5 Diabetes Centre, Bankstown-Lidcombe Hospital, Bankstown, New South Wales, Australia
Corresponding author: Alison Harmer, a.harmer{at}usyd.edu.au
Abstract
OBJECTIVE —To investigate sprint-training effects on muscle metabolism during exercise in subjects with (type 1 diabetic group) and
without (control group) type 1 diabetes.
RESEARCH DESIGN AND METHODS —Eight subjects with type 1 diabetes and seven control subjects, matched for age, BMI, and maximum oxygen uptake ( V̇ o 2peak ), undertook 7 weeks of sprint training. Pretraining, subjects cycled to exhaustion at 130% V̇ o 2peak . Posttraining subjects performed an identical test. Vastus lateralis biopsies at rest and immediately after exercise were
assayed for metabolites, high-energy phosphates, and enzymes. Arterialized venous blood drawn at rest and after exercise was
analyzed for lactate and [H + ]. Respiratory measures were obtained on separate days during identical tests and during submaximal tests before and after
training.
RESULTS —Pretraining, maximal resting activities of hexokinase, citrate synthase, and pyruvate dehydrogenase did not differ between
groups. Muscle lactate accumulation with exercise was higher in type 1 diabetic than nondiabetic subjects and corresponded
to indexes of glycemia (A1C, fasting plasma glucose); however, glycogenolytic and glycolytic rates were similar. Posttraining,
at rest, hexokinase activity increased in type 1 diabetic subjects; in both groups, citrate synthase activity increased and
pyruvate dehydrogenase activity decreased; during submaximal exercise, fat oxidation was higher; and during intense exercise,
peak ventilation and carbon dioxide output, plasma lactate and [H + ], muscle lactate, glycogenolytic and glycolytic rates, and ATP degradation were lower in both groups.
CONCLUSIONS —High-intensity exercise training was well tolerated, reduced metabolic destabilization (of lactate, H + , glycogenolysis/glycolysis, and ATP) during intense exercise, and enhanced muscle oxidative metabolism in young adults with
type 1 diabetes. The latter may have clinically important health benefits.
Footnotes
Published ahead of print at http://care.diabetesjournals.org on 20 August 2008.
Clinical trial reg. no. ACTRN012606000368538, clinicaltrials.org
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore
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Accepted August 12, 2008.
Received February 13, 2008.
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