Aging in the cerebellum and hippocampus and associated behaviors over the adult life span of CB6F1 mice

• Published in: Neuroscience Vol. 247; pp. 335 - 350
• Main Authors: Kennard, J.A, Brown, K.L, Woodruff-Pak, D.S
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 05-09-2013; Elsevier
• Subjects: age sensitivity; aging; Aging - metabolism; Animals; Biological and medical sciences; CB6F1; cerebellum; Cerebellum - metabolism; Cerebellum - pathology; Conditioning, Eyelid - physiology; Fundamental and applied biological sciences. Psychology; hippocampus; Hippocampus - metabolism; Hippocampus - pathology; learning; Learning - physiology; Longevity - physiology; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurology; Organ Size; Vertebrates: nervous system and sense organs; MWM; Morris water maze; hippocampus; CRs; Spontaneous Motor Activity Recording and Tracking; conditioned responses; learning; CB6F1; cerebellum; SD; eyeblink classical conditioning; CPFE; analysis of variance; context pre-exposure facilitation effect; ANOVA; electromyography; age sensitivity; aging; SMART; EBCC; EMG; standard deviation; Cerebellum; Senescence; Rodentia; Central nervous system; Longevity; Encephalon; Learning; Vertebrata; Sensitivity; Mammalia; Acquisition process; Mouse; Animal; Behavior; Age; Hippocampus
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.06.002

Highlights • Compared age effects on hippocampus- and cerebellum-dependent learning in mice. • Tasks were chosen to increase the ability to detect age-related changes in learning. • Rotorod impairment began at 12 mo and correlated with Purkinje neuron loss. • Trace EBCC deficits began at 25 mo, but CPFE fear conditioning was not impaired. • Results support the finding of differential aging in the hippocampus and cerebellum.