Birth weight, intrauterine growth restriction and nutritional status in childhood in relation to grip strength in adults: from the 1982 Pelotas (Brazil) birth cohort

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 32; no. 2; pp. 228 - 235
• Main Authors: Bielemann, Renata Moraes, Ph.D, Gigante, Denise Petrucci, Ph.D, Horta, Bernardo Lessa, M.D., Ph.D
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-02-2016; Elsevier Limited; Elsevier Science
• Subjects: Absorptiometry, Photon; Adult; Adults; Age; Applied Nutritional Investigation; Birth Weight; Body composition; Body Mass Index; Brazil; Child development; Child, Preschool; Childbirth & labor; Children; Cohort analysis; Cohort Studies; Confidence intervals; Female; Females; Fetal Growth Retardation - diagnosis; Fetuses; Follow-Up Studies; Gastroenterology and Hepatology; Gender differences; Gestational Age; Grip strength; Hand strength; Hand Strength - physiology; Health risk assessment; Humans; Linear Models; Low income groups; Male; Males; Maternal Nutritional Physiological Phenomena; Muscle Strength; Musculoskeletal system; Nutrition; Nutritional Status; Postnatal Care; Pregnancy; Prenatal Care; Prenatal development; Socioeconomic Factors; Urban areas; Young adults; Brazil; Pelotas Brazil; Birth weight; Hand strength; Nutritional status; Cohort studies
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2015.08.014

Abstract Objective The aim of this study was to evaluate the association among birth weight, intrauterine growth, and nutritional status in childhood with grip strength in young adults from the 1982 Pelotas (Brazil) birth cohort. Methods In 1982, the hospital live births of Pelotas were followed. In 2012, grip strength was evaluated using a hand dynamometer and the best of the six measurements was used. Birth weight was analyzed as z -score for gestational age according to Williams (1982) curve. Weight-for-age, weight-for-length/height, and length/height-for-age at 2 and 4 y were analyzed in z -scores according to 2006 World Health Organization Child Growth Standards. Lean mass at 30 y was included as possible mediator using the g-computation formula. Results In 2012, 3701 (68.1%) individuals were interviewed and 3470 were included in the present analyses. An increase of 1 z -score in birth weight was associated with an increase of 1.5 kg in grip strength in males (95% confidence interval, 1.1–1.9). Positive effect of birth weight on grip strength was found in females. Grip strength was greater in individuals who were born with appropriate size for gestational age and positively associated with weight- and length/height-for-age z -score at 2 and 4 y of age. A positive association between birth weight and grip strength was only partially mediated by adult lean mass (50% and 33% of total effect in males and females), whereas direct effect of weight at 2 y was found only in males. Conclusions It is suggested that good nutrition in prenatal and early postnatal life has a positive influence on adult muscle strength. The results from birth weight were suggestive of fetal programming on grip strength measurement.