Pulmonary veno-occlusive disease following hematopoietic stem cell transplantation: a rare model of endothelial dysfunction

• Published in: Bone marrow transplantation (Basingstoke) Vol. 41; no. 8; pp. 677 - 686
• Main Authors: Bunte, M C, Patnaik, M M, Pritzker, M R, Burns, L J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-04-2008; Nature Publishing Group
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Bone marrow; Bone marrow, stem cells transplantation. Graft versus host reaction; Care and treatment; Cell Biology; Complications; Complications and side effects; Endothelium - physiology; Fibrinolytic Agents - therapeutic use; Hematology; Hematopoietic Stem Cell Transplantation - adverse effects; Hematopoietic stem cells; Humans; Internal Medicine; Liver diseases; Lung diseases; Medical sciences; Medicine; Medicine & Public Health; Polydeoxyribonucleotides - therapeutic use; Public Health; Pulmonary Veno-Occlusive Disease - etiology; Pulmonary Veno-Occlusive Disease - physiopathology; review; Risk factors; Stem cell transplantation; Stem Cells; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation; Veno-occlusive disease; United States; pulmonary veno-occlusive disease; endothelial dysfunction; defibrotide; hematopoietic stem cell transplant; Lung disease; Venoocclusive disease; Hematology; Respiratory disease; Stem cell; Defibrotide; Hematopoietic cell; Anticoagulant; Endothelial dysfunction; Graft; Models; Fibrinolytic
• ISSN: 0268-3369; 1476-5365
• DOI: 10.1038/sj.bmt.1705990

Veno-occlusive disease is among the most serious complications following hematopoietic stem cell transplantation. While hepatic veno-occlusive disease occurs more commonly, the pulmonary variant remains quite rare and often goes unrecognized antemortem. Endothelial damage may represent the pathophysiologic foundation of these clinical syndromes. Recent advances in the treatment of hepatic veno-occlusive disease may have application to its pulmonary counterpart.