Combining the Fibrinogen/Albumin Ratio and Systemic Inflammation Response Index Predicts Survival in Resectable Gastric Cancer

• Published in: Gastroenterology research and practice Vol. 2020; no. 2020; pp. 1 - 9
• Main Authors: Teng, Lisong, Wang, Haiyong, Lu, Yi-Min, Wang, Weibin, Ding, Yongfeng, Zhang, Junbin, Wang, Haohao
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Age; Blood platelets; Cancer; Development and progression; Gastric cancer; Inflammation; Laboratories; Lymphocytes; Medical prognosis; Metastasis; Neutrophils; Patient outcomes; Prognosis; Stomach cancer; Studies; Surgery; Tumors; China; Taiwan
• ISSN: 1687-6121; 1687-630X
• DOI: 10.1155/2020/3207345

Aims. Predicting the prognosis of gastric cancer using tumour-node-metastasis (TNM) staging is difficult as patients with the same TNM stage exhibit different prognoses. Methods. This study investigated the prognostic value of the preoperative fibrinogen/albumin ratio (FAR)-systemic inflammation response index (SIRI) score in resectable gastric cancer (rGC). Results. Clinicopathological features of 231 rGC patients were analysed retrospectively. Patients were divided into three groups: FAR-SIRI score 2 (FAR≥0.071 and SIRI≥0.84), 1 (FAR<0.071 and SIRI≥0.84), and 0 (SIRI<0.84). Higher FAR-SIRI scores were associated with larger tumours, poorer differentiation, and advanced TNM stage (P<0.05). Compared to those with FAR-SIRI scores of 0, patients with scores of 2 had poorer overall survival (OS). The FAR-SIRI score was an independent prognostic factor for OS in rGC. Conclusion. The present data demonstrated that FAR-SIRI scores predicted radical gastric cancer surgical outcomes and may serve as a blood marker for identifying high-risk patients.