Voluntary exercise protects hippocampal neurons from trimethyltin injury: Possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity

• Published in: Brain, behavior, and immunity Vol. 25; no. 6; pp. 1063 - 1077
• Main Authors: Funk, Jason A, Gohlke, Julia, Kraft, Andrew D, McPherson, Christopher A, Collins, Jennifer B, Jean Harry, G
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01-08-2011
• Subjects: Allergy and Immunology; Animals; Chemokines - biosynthesis; Chemokines - genetics; Epilepsy, Tonic-Clonic - chemically induced; Exercise; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - pathology; Interleukin-6; Interleukin-6 - biosynthesis; Interleukin-6 - deficiency; Interleukin-6 - genetics; Interleukin-6 - physiology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Neurological; Myeloid Differentiation Factor 88 - biosynthesis; Myeloid Differentiation Factor 88 - genetics; Nerve Tissue Proteins - biosynthesis; Nerve Tissue Proteins - genetics; Neuroinflammation; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Neuroprotection; Neurotoxins - toxicity; Physical Conditioning, Animal - physiology; Psychiatry; Radiation Chimera; Random Allocation; Receptors, Tumor Necrosis Factor - biosynthesis; Receptors, Tumor Necrosis Factor - drug effects; Receptors, Tumor Necrosis Factor - physiology; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Specific Pathogen-Free Organisms; TNFα; Tremor - chemically induced; Trimethyltin; Trimethyltin Compounds - toxicity; Tumor Necrosis Factor-alpha - physiology; Up-Regulation; Neuroprotection; TNFα; Exercise; Neuroinflammation; Trimethyltin; Hippocampus; Interleukin-6
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1016/j.bbi.2011.03.012

Highlight ► Voluntary exercise elevates hippocampal IL-6 offering protection against chemical-induced hippocampal injury associated with TNF receptor activation.