Proportional mouse model for aerosol infection by influenza

Aims The aim of this study was to demonstrate a prototype tool for measuring infectivity of an aerosolized human pathogen – influenza A/PR/8/34 (H1N1) virus – using a small‐animal model in the Controlled Aerosol Test System (CATS). Methods and Results Intranasal inoculation of nonadapted H1N1 virus...

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Bibliographic Details
Published in:	Journal of applied microbiology Vol. 113; no. 4; pp. 767 - 778
Main Authors:	McDonald, R.S., Sambol, A.R., Heimbuch, B.K., Brown, T.L., Hinrichs, S.H., Wander, J.D.
Format:	Journal Article
Language:	English
Published:	Oxford Blackwell Publishing Ltd 01-10-2012 Blackwell Oxford University Press John Wiley and Sons Inc
Subjects:	Administration, Inhalation Administration, Intranasal aerosol Aerosols Aerosols - adverse effects Animals Atmosphere Exposure Chambers Biological and medical sciences Disease Models, Animal Female Fundamental and applied biological sciences. Psychology H1N1 infection Influenza Influenza A Virus, H1N1 Subtype - pathogenicity inhalation Inhalation Exposure Lung - pathology Lung - virology Mice Mice, Inbred BALB C Mice, Inbred C57BL Microbiology mouse Original Pathology respiratory protection Rodents Applied microbiology Rodentia H1N1 Inhalation Infection Vertebrata Mammalia Mouse Viral disease Influenza Aerosols Models Respiration respiratory protection Protection aerosol
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