A New Look at MHC and Autoimmune Disease

• Published in: Science (American Association for the Advancement of Science) Vol. 284; no. 5415; pp. 749 - 751
• Main Authors: Ridgway, William M., Fassò, Marcella, Fathman, C. Garrison
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 30-04-1999; American Association for the Advancement of Science; The American Association for the Advancement of Science
• Subjects: Animals; Antigen Presentation; Antigen-Presenting Cells - immunology; Antigens; Autoantigens - immunology; Autoimmune diseases; Autoimmune Diseases - immunology; Autoimmunity (experimental aspects and models); Biological and medical sciences; Diabetes; Diabetes Mellitus, Type 1 - immunology; Disease Incidence; Feedback (Response); Fundamental and applied biological sciences. Psychology; Fundamental immunology; Genes, MHC Class II; Genetic aspects; Histocompatibility Antigens Class II - immunology; Immunization; Immunology; Major histocompatibility complex; Medical research; Mice; Mice, Inbred NOD; Molecules; Perspectives; Positive selection; Receptors, Antigen, T-Cell - immunology; Self Tolerance; T cell antigen receptors; T lymphocytes; T-Lymphocytes - immunology; Thymocytes; Thymus Gland - immunology; Type 1 diabetes mellitus; Autoimmunity; T cell receptor; Thymocyte; Major histocompatibility system; Rodentia; Autoimmune disease; Vertebrata; Mammalia; Gene; Mouse; Animal; Clonal selection; Immunologic repertoire
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.284.5415.749

Recent results in an animal model of autoimmune diabetes suggest a new hypothesis to explain the role of major histocompatibility complexes (MHCs) in autoimmunity.