The propionate-GPR41 axis in infancy protects from subsequent bronchial asthma onset

• Published in: Gut microbes Vol. 15; no. 1; p. 2206507
• Main Authors: Ito, Takashi, Nakanishi, Yumiko, Shibata, Ryohei, Sato, Noriko, Jinnohara, Toshi, Suzuki, Sayo, Suda, Wataru, Hattori, Masahira, Kimura, Ikuo, Nakano, Taiji, Yamaide, Fumiya, Shimojo, Naoki, Ohno, Hiroshi
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 31-12-2023; Taylor & Francis Group
• Subjects: allergic disease; Animals; Asthma - prevention & control; Bronchial asthma; Child; Disease Susceptibility; Fatty Acids, Volatile - metabolism; Female; Gastrointestinal Microbiome; GPR41; human birth cohort; Humans; Infant; Intestines; lactation period; Mice; microbiota; propionate; Propionates; Research Paper; Scfas; Tlrs; microbiota; Bronchial asthma; GPR41; Scfas; lactation period; allergic disease; Tlrs; propionate; human birth cohort
• ISSN: 1949-0976; 1949-0984
• DOI: 10.1080/19490976.2023.2206507

Evidence has accumulated that gut microbiota and its metabolites, in particular the short-chain fatty acid propionate, are significant contributors to the pathogenesis of a variety of diseases. However, little is known regarding its impact on pediatric bronchial asthma, one of the most common allergic diseases in childhood. This study aimed to elucidate whether, and if so how, intestinal propionate during lactation is involved in the development of bronchial asthma. We found that propionate intake through breast milk during the lactation period resulted in a significant reduction of airway inflammation in the offspring in a murine house dust mite-induced asthma model. Moreover, GPR41 was the propionate receptor involved in suppressing this asthmatic phenotype, likely through the upregulation of Toll-like receptors. In translational studies in a human birth cohort, we found that fecal propionate was decreased one month after birth in the group that later developed bronchial asthma. These findings indicate an important role for propionate in regulating immune function to prevent the pathogenesis of bronchial asthma in childhood.