Mechanisms controlling cell cycle exit upon terminal differentiation

Coordinating terminal differentiation with permanent exit from the cell cycle is crucial for proper organogenesis, yet how the cell cycle is blocked in differentiated tissues remains unclear. Important roles for retinoblastoma family proteins and Cyclin-dependent kinase inhibitors have been delineat...

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Bibliographic Details
Published in:	Current opinion in cell biology Vol. 19; no. 6; pp. 697 - 704
Main Authors:	Buttitta, Laura A, Edgar, Bruce A
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-12-2007
Subjects:	Animals Cell Cycle - physiology Cell Differentiation - physiology Gene Expression Regulation Humans Internal Medicine Signal Transduction
Online Access:	Get full text
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Summary:	Coordinating terminal differentiation with permanent exit from the cell cycle is crucial for proper organogenesis, yet how the cell cycle is blocked in differentiated tissues remains unclear. Important roles for retinoblastoma family proteins and Cyclin-dependent kinase inhibitors have been delineated, but in many cases it remains unclear what triggers cell cycle exit. This review focuses on describing recent advances in deciphering how terminal differentiation and exit from the cell cycle are coordinated.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0955-0674 1879-0410
DOI:	10.1016/j.ceb.2007.10.004