Emerging role of Fatty acid synthase in tumor initiation: implications for cancer prevention

Targeting metabolic reprogramming has emerged as a promising strategy for therapeutic intervention in cancer. We identify that fatty acid synthase (FASN) is essential for cancer initiation playing a critical role in acquiring three-dimensional (3D) growth properties during transformation. In vivo in...

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Bibliographic Details
Published in:	Molecular & cellular oncology Vol. 7; no. 2; p. 1709389
Main Authors:	Bueno, Maria J., Quintela-Fandino, Miguel
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 03-03-2020 Taylor & Francis Group
Subjects:	anchorage-independent growth Author's Views cancer metabolism cancer prevention FASN cancer metabolism cancer prevention anchorage-independent growth FASN
Online Access:	Get full text
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Summary:	Targeting metabolic reprogramming has emerged as a promising strategy for therapeutic intervention in cancer. We identify that fatty acid synthase (FASN) is essential for cancer initiation playing a critical role in acquiring three-dimensional (3D) growth properties during transformation. In vivo inhibition of FASN before oncogenic activation prevents tumor development and invasive growth suggesting that FASN could be a potential target for cancer prevention.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2372-3556 2372-3556
DOI:	10.1080/23723556.2019.1709389