Pneumococcal serotype distribution and antimicrobial resistance in Chinese children hospitalized for pneumonia

• Published in: Vaccine Vol. 29; no. 12; pp. 2296 - 2301
• Main Authors: Yao, Kai-Hu, Wang, Li-Bo, Zhao, Gen-Ming, Zheng, Yue-Jie, Deng, Li, Huang, Jing-Fu, Wang, Jie-Xiu, Zhao, Rui-Zhen, Deng, Qiu-Lian, Hu, Ying-Hui, Yu, Sang-Jie, Yang, Yong-Hong, Young, Mariano
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 09-03-2011; Elsevier; Elsevier Limited
• Subjects: Age; Allergy and Immunology; Anti-Bacterial Agents - pharmacology; antibiotic resistance; Antibiotics; Antimicrobial agents; Applied microbiology; Bacteriology; Biological and medical sciences; Catheters; Child, Preschool; Children; Children & youth; China - epidemiology; Developing countries; Drug resistance; Drug Resistance, Multiple, Bacterial; Ear diseases; Epidemiology; Erythromycin; Fundamental and applied biological sciences. Psychology; Hospitals; Humans; Infant; Infection; Laboratories; LDCs; Microbial Sensitivity Tests; Microbiology; Miscellaneous; Penicillin; Pneumococcal Infections - epidemiology; Pneumococcal Infections - microbiology; Pneumococcal Vaccines - administration & dosage; Pneumonia; Prospective Studies; Serotype; Serotypes; Serotyping; Streptococcus infections; Streptococcus pneumoniae; Streptococcus pneumoniae - classification; Streptococcus pneumoniae - drug effects; Streptococcus pneumoniae - isolation & purification; Studies; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); China; Drug resistance; Serotype; Streptococcus pneumoniae; Human; Lung disease; Pneumonia; Respiratory disease; Antimicrobial agent; Resistance; Streptococcaceae; Bacteria; Micrococcales; Child
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2011.01.027

Abstract A prospective study was performed to determine serotype distribution and antimicrobial resistance in Streptococcus pneumoniae ( S. pneumoniae ) from Chinese children <5 years old meeting pneumonia criteria. A total of 3865 children were enrolled and 338 S. pneumoniae isolates were obtained. The most frequent serotypes were 19F (55.6%), 19A (13.9%), 23F (10.1%), 6B (4.7%), and 14 (3.6%). The 7-, 10- and 13-valent conjugate vaccines, respectively, covered 76.3%, 76.9%, and 92.3% of isolates. Out of the isolates, six (1.8%) were penicillin resistant. All except 1 of the isolates were resistant to erythromycin. Serotype 19A showed the highest drug resistance. The use of PCV7 has the potential to prevent a substantial number of pneumococcal infections. However, PCV13 is likely to prevent more episodes of pneumococcal disease in China because of the high rates of 19A.