Menstrual disturbances in various thyroid diseases

• Published in: Endocrine Journal Vol. 57; no. 12; pp. 1017 - 1022
• Main Authors: Kakuno, Yoko, Amino, Nobuyuki, Kanoh, Maki, Kawai, Miho, Fujiwara, Miyuki, Kimura, Misao, Kamitani, Ayako, Saya, Kaori, Shakuta, Reiko, Nitta, Sanae, Hayashida, Yasuko, Kudo, Takumi, Kubota, Sumihisa, Miyauchi, Akira
• Format: Journal Article
• Language: English
• Published: Japan The Japan Endocrine Society 2010
• Subjects: Adult; Amenorrhea; Amenorrhea - complications; Amenorrhea - epidemiology; Female; Graves Disease - complications; Humans; Hyperthyroidism; Hyperthyroidism - complications; Hypothyroidism; Hypothyroidism - complications; Menstrual disturbance; Menstruation Disturbances - complications; Menstruation Disturbances - epidemiology; Middle Aged; Oligomenorrhea - complications; Oligomenorrhea - epidemiology; Prospective Studies; Thyroid Diseases - complications; Thyroid Neoplasms - complications; Thyroiditis - complications
• ISSN: 0918-8959; 1348-4540
• DOI: 10.1507/endocrj.K10E-216

The prevalence of menstrual disturbances, including secondary amenorrhea, hypomenorrhea, oligomenorrhea, hypermenorrhea, polymenorrhea and irregular menstrual cycle were prospectively examined in 586 patients with hyperthyroidism due to Graves’ disease, 111 with hypothyroidism, 558 with euthyroid chronic thyroiditis, 202 with painless thyroiditis and 595 with thyroid tumor. In the overall patient group, the prevalence did not different from that in 105 healthy controls. However, patients with severe hyperthyroidism showed a higher prevalence of secondary amenorrhea (2.5%) and hypomenorrhea (3.7%) than those (0.2% and 0.9%, respectively) with mild or moderate hyperthyroidism. Moreover, patients with severe hypothyroidism had a higher prevalence (34.8%) of menstrual disturbances than mild-moderate cases (10.2%). Menstrual disturbances in thyroid dysfunction were less frequent than previously thought.