Research progress on antitumor mechanisms and molecular targets of Inula sesquiterpene lactones

• Published in: Chinese medicine Vol. 18; no. 1; p. 164
• Main Authors: Cao, Fei, Chu, Chu, Qin, Jiang-Jiang, Guan, Xiaoqing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18-12-2023; BioMed Central; BMC
• Subjects: Antineoplastic drugs; Antitumor; Antitumor activity; Antitumor agents; Apoptosis; Asthma; Biological activity; Cancer therapies; Cell cycle; Cell division; Cell growth; Chemotherapy; Cytotoxicity; Drug development; Drugs; Inflammation; Inula; Inula sesquiterpene lactones; Kinases; Lactones; Mechanisms of action; Mitochondria; Molecular target; Natural products; Neuroprotection; Proteins; R&D; Research & development; Review; Sesquiterpene lactones; Structure–activity relationship; Tumors; Vincristine; Mechanisms of action; Molecular target; Inula sesquiterpene lactones; Structure–activity relationship; Antitumor
• ISSN: 1749-8546; 1749-8546
• DOI: 10.1186/s13020-023-00870-1

The pharmacological effects of natural product therapy have received sigificant attention, among which terpenoids such as sesquiterpene lactones stand out due to their biological activity and pharmacological potential as anti-tumor drugs. Inula sesquiterpene lactones are a kind of sesquiterpene lactones extracted from Inula species. They have many pharmacological activities such as anti-inflammation, anti-asthma, anti-tumor, neuroprotective and anti-allergic. In recent years, more and more studies have proved that they are important candidate drugs for the treatment of a variety of cancers because of its good anti-tumor activity. In this paper, the structure, structure-activity relationship, antitumor activities, mechanisms and targets of Inula sesquiterpene lactones reported in recent years were reviewed in order to provide clues for the development of novel anticancer drugs.