Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials

• Published in: Applied microbiology and biotechnology Vol. 102; no. 5; pp. 2075 - 2089
• Main Authors: Bassegoda, Arnau, Ivanova, Kristina, Ramon, Eva, Tzanov, Tzanko
• Format: Journal Article Publication
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-03-2018; Springer; Springer Nature B.V
• Subjects: Anti-infective agents; antibiofouling; Antibiotic resistance; Antibiotics; Antibiòtics; Antiinfectives and antibacterials; Antimicrobial agents; antimicrobial peptides; Bacteria; Bacterial diseases; Biofilms; Biomedical and Life Sciences; Biotechnology; Biotecnologia; Dosage and administration; Drug resistance; Enginyeria de teixits; Enginyeria química; Global health; Hydrogels; Life Sciences; Microbial drug resistance; Microbial Genetics and Genomics; Microbiology; Mini-Review; Mode of action; Morbidity; nano-antimicrobial materials; Nanoparticles; Nanopartícules; Prevention; quorum sensing; therapeutic use; Tissue engineering; Virulence; virulence factors; Àrees temàtiques de la UPC; Ús terapèutic; Quorum sensing; Nano-antimicrobial materials; Virulence factors; Antibiotic resistance; Antimicrobial peptides; Antibiofouling
• ISSN: 0175-7598; 1432-0614
• DOI: 10.1007/s00253-018-8776-0

Drug resistance occurrence is a global healthcare concern responsible for the increased morbidity and mortality in hospitals, time of hospitalisation and huge financial loss. The failure of the most antibiotics to kill “superbugs” poses the urgent need to develop innovative strategies aimed at not only controlling bacterial infection but also the spread of resistance. The prevention of pathogen host invasion by inhibiting bacterial virulence and biofilm formation, and the utilisation of bactericidal agents with different mode of action than classic antibiotics are the two most promising new alternative strategies to overcome antibiotic resistance. Based on these novel approaches, researchers are developing different advanced materials (nanoparticles, hydrogels and surface coatings) with novel antimicrobial properties. In this review, we summarise the recent advances in terms of engineered materials to prevent bacteria-resistant infections according to the antimicrobial strategies underlying their design.