Predictors of Occult Cancer in Acute Ischemic Stroke Patients

• Published in: Journal of stroke and cerebrovascular diseases Vol. 24; no. 6; pp. 1324 - 1328
• Main Authors: Cocho, Dolores, MD, PhD, Gendre, Jordi, MD, Boltes, Anuncia, MD, Espinosa, Jordi, MD, Ricciardi, Ana C., MD, Pons, Jordi, MD, Jimenez, Marta, MD, Otermin, Pilar, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-06-2015
• Subjects: Aged; Aged, 80 and over; Biomarkers - blood; Brain Ischemia - blood; Brain Ischemia - complications; C-Reactive Protein - metabolism; cancer; Cardiovascular; Female; Fibrinogen - metabolism; Humans; ischemic stroke; Male; Middle Aged; Neoplasms - blood; Neoplasms - complications; Neoplasms - diagnosis; Neurology; occult malignancy; Retrospective Studies; Risk Factors; Sensitivity and Specificity; Severity of Illness Index; Stroke; Stroke - blood; Stroke - complications; Stroke; cancer; ischemic stroke; occult malignancy
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2015.02.006

Background We investigated the prevalence of occult malignancy (OM) in acute ischemic stroke patients to evaluate if any biological marker could help to detect the presence of OM. Methods We retrospectively reviewed all ischemic stroke patients during 48 months. We did not perform any screening for OM. Demographic data, vascular risk factors, routine blood chemistry with fibrinogen and C-reactive protein (CRP), National Institutes of Health Stroke Scale (NIHSS), and etiological subtype of stroke according to Trial of Org 10172 in Acute Stroke Treatment criteria were analyzed. The patients were divided into 2 groups (Non-OM versus OM). Results We analyzed 631 patients with acute ischemic stroke. The mean age was 69.7 ± 12.7 years, and 59% were men. The distribution of vascular risk factors, etiological subgroups, and NIHSS was comparable between both groups. We detected 13 cases (2.1%) with OM, and this percentage was higher in patients with stroke of undetermined etiology (5.3%). We detected significant higher levels of fibrinogen and CRP in patients with stroke of undetermined cause with OM. Receiver operating characteristic curves showed a sensitivity of 75% and specificity of 96% for levels of CRP more than 20 mg/L, and a sensitivity of 67% and specificity of 91% for fibrinogen levels greater than 600 mg/dL. Conclusions OM was present in 2.1 % of overall patients, and 5.3% of patients with stroke of undetermined cause. Baseline levels of fibrinogen more than 600 mg/dL or CRP greater than 20 mg/L in patients with undetermined stroke might be good predictors of OM.