Bladder carcinosarcoma treated by cystectomy and adjuvant chemotherapy with good outcomes: a case report

• Published in: Journal of medical case reports Vol. 17; no. 1; p. 320
• Main Authors: Kouhen, Fadila, Dahbi, Zineb, Afif, Mohammed, Chihabeddine, Meriem, Errafiy, Nadia, Oqbani, Kenza, Omor, Youssef, Elhossini, Amal
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19-07-2023; BioMed Central; BMC
• Subjects: Abdomen; Adjuvant treatment; Adjuvants; Aged; Analysis; Bladder cancer; Bladder carcinosarcoma; Cancer; Cancer therapies; Carcinoma, Transitional Cell - pathology; Carcinosarcoma - drug therapy; Carcinosarcoma - pathology; Case Report; Case reports; Chemotherapy; Chemotherapy, Adjuvant; Clinical outcomes; Cystectomy; Cytokeratin; Diabetes; Hematuria; Humans; Intervention; Lymphatic system; Male; Medical prognosis; Metastasis; Outcomes; Patients; Pelvic Neoplasms - surgery; Radiation therapy; Soft Tissue Neoplasms - surgery; Stem cells; Tumors; Urinary Bladder - diagnostic imaging; Urinary Bladder - pathology; Urinary Bladder - surgery; Urinary Bladder Neoplasms - drug therapy; Urinary Bladder Neoplasms - surgery; Urogenital system; Urological surgery; Morocco; Bladder carcinosarcoma; Chemotherapy; Cystectomy; Outcomes
• ISSN: 1752-1947; 1752-1947
• DOI: 10.1186/s13256-023-04028-3

Primary carcinosarcoma of the bladder is a rare and highly aggressive tumor, representing less than 1% of all bladder neoplasms. There is no specific treatment guideline has for carcinosarcoma of the bladder, and majority of published patients was treated exclusively by surgery.
We report a case of 65-year-old Moroccan man, presented with macroscopic hematuria, pollakiuria and painful urination. Histological analysis showed a biphasic epithelial and mesenchymal proliferation, with invasion of lamina propria and muscularis, compatible with diagnosis of bladder carcinosarcoma. The patient was treated with cystectomy and adjuvant chemotherapy based on gemcitabin-cisplatin, 18 months after treatment, patient still free of recurrence.
Carcinosarcoma of the urinary bladder is a rare and aggressive tumor regardless treatment. A multidisciplinary management based on radical cystectomy and combined adjuvant treatments can improve prognosis. In this work, we suggest to propose adjuvant chemotherapy whenever possible.