No benefit of longer eradication therapy of Pseudomonas aeruginosa primoinfections in pediatric cystic fibrosis

• Published in: BMC research notes Vol. 12; no. 1; pp. 115 - 6
• Main Authors: Claude, F, Rochat, I, Hafen, G M
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04-03-2019; BioMed Central; BMC
• Subjects: Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics; Child; Child health; Children & youth; Ciprofloxacin; Ciprofloxacin - administration & dosage; Ciprofloxacin - pharmacology; Clinical Protocols; Confidence intervals; Cystic fibrosis; Cystic Fibrosis - complications; Cysts; Eradication; Eradication protocol; Female; Fibrosis; Health aspects; Humans; Infection; Infections; Lung diseases; Male; Methicillin; Outcome and Process Assessment, Health Care; Outpatient care facilities; Pediatrics; Primoinfection; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Pseudomonas Infections - drug therapy; Pseudomonas Infections - etiology; Research Note; Respiratory function; Retrospective Studies; Risk factors; Success; Time Factors; Tobramycin; Tobramycin - administration & dosage; Tobramycin - pharmacology; Cystic fibrosis; Pseudomonas aeruginosa; Primoinfection; Eradication protocol
• ISSN: 1756-0500; 1756-0500
• DOI: 10.1186/s13104-019-4157-8

Patients with cystic fibrosis are more susceptible than members of the general population to lung infections. Infections with Pseudomonas aeruginosa require particular attention, because they may accelerate the deterioration of lung function if not adequately treated. This study assessed the eradication rate of P. aeruginosa primoinfections, with a protocol of inhaled tobramycin and oral ciprofloxacin over a 3 months' period.
Retrospective single-center study from June 1st, 2007 to December 31st, 2015. Inclusion of 28 pediatric patients (11 females, 17 males), with a total of 49 primoinfections. Overall success rate of 67.3%, which is similar or even inferior to figures published in the literature.