Noncoding RNAs link metabolic reprogramming to immune microenvironment in cancers

• Published in: Journal of hematology and oncology Vol. 14; no. 1; pp. 169 - 26
• Main Authors: Zhang, Yiyin, Mao, Qijiang, Xia, Qiming, Cheng, Jiaxi, Huang, Zhengze, Li, Yirun, Chen, Peng, Yang, Jing, Fan, Xiaoxiao, Liang, Yuelong, Lin, Hui
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15-10-2021; BioMed Central; BMC
• Subjects: Adenosine; Amino acids; Animals; Antigens; Apoptosis; B cells; Bioinformatic approach; Cancer; Cytotoxicity; Enzymes; Fatty acids; Gene Expression Regulation, Neoplastic; Genetic transcription; Hematology; Humans; Immune microenvironment; Immune response; Immunity; Immunotherapy; Infiltration; Lymphocytes; Metabolic Networks and Pathways; Metabolism; Metabolites; Metastases; Microenvironments; miRNA; Neoplasms - genetics; Neoplasms - immunology; Neoplasms - metabolism; Noncoding RNAs; Nutrient requirements; Oncology; Physiological aspects; Review; RNA, Long Noncoding - genetics; RNA, Long Noncoding - immunology; RNA, Long Noncoding - metabolism; TIMELnc manual; Transcription; Tumor cells; Tumor metabolism; Tumor Microenvironment; Tumors; Immune microenvironment; Tumor metabolism; TIMELnc manual; Bioinformatic approach; Noncoding RNAs
• ISSN: 1756-8722; 1756-8722
• DOI: 10.1186/s13045-021-01179-y

Altered metabolic patterns in tumor cells not only meet their own growth requirements but also shape an immunosuppressive microenvironment through multiple mechanisms. Noncoding RNAs constitute approximately 60% of the transcriptional output of human cells and have been shown to regulate numerous cellular processes under developmental and pathological conditions. Given their extensive action mechanisms based on motif recognition patterns, noncoding RNAs may serve as hinges bridging metabolic activity and immune responses. Indeed, recent studies have shown that microRNAs, long noncoding RNAs and circRNAs are widely involved in tumor metabolic rewiring, immune cell infiltration and function. Hence, we summarized existing knowledge of the role of noncoding RNAs in the remodeling of tumor metabolism and the immune microenvironment, and notably, we established the TIMELnc manual, which is a free and public manual for researchers to identify pivotal lncRNAs that are simultaneously correlated with tumor metabolism and immune cell infiltration based on a bioinformatic approach.