Is the baboon model appropriate for endometriosis studies?

• Published in: Fertility and sterility Vol. 96; no. 3; pp. 728 - 733.e3
• Main Authors: Dehoux, Jean-Paul, D.V.M., Ph.D, Defrère, Sylvie, Ph.D, Squifflet, Jean, M.D, Donnez, Olivier, M.D, Polet, Roland, M.D, Mestdagt, Mélanie, Ph.D, Foidart, Jean-Michel, M.D., Ph.D, Van Langendonckt, Anne, Ph.D, Donnez, Jacques, M.D., Ph.D
• Format: Journal Article Web Resource
• Language: English
• Published: New York, NY Elsevier Inc 01-09-2011; Elsevier
• Subjects: Animals; baboon model; Biological and medical sciences; cervical resection; Cervix Uteri - pathology; Cervix Uteri - surgery; Disease Models, Animal; Endometriosis - epidemiology; Endometriosis - pathology; Endometriosis - physiopathology; Female; Female genital diseases; Follow-Up Studies; Gynecology. Andrology. Obstetrics; hematometra; Human health sciences; Incidence; Internal Medicine; Laparoscopy; Medical sciences; Menstrual Cycle - physiology; menstruation; Médecine de la reproduction (Gynécologie, andrologie, obstétrique); Non tumoral diseases; Obstetrics and Gynecology; Papio; Prevalence; Remission, Spontaneous; Reproductive medicine (gynecology, andrology, obstetrics); resection; retrograde menstruation; Sciences de la santé humaine; Spontaneous and induced endometriosis; uterus; Belgium; Kenya; retrograde menstruation; Spontaneous and induced endometriosis; hematometra; baboon model; cervical resection; Menstruation; Resection; Gynecology; Retrograde; Spontaneous; Endometriosis; Uterine cervix; Congenital disease; Obstetrics; Female genital diseases; Malformation; Uterine diseases; Hematometry; Models
• ISSN: 0015-0282; 1556-5653; 1556-5653
• DOI: 10.1016/j.fertnstert.2011.06.037

Objective To determinethe prevalence of spontaneous endometriosis andthe incidence of induced endometriosis after endocervical canal resection in baboons. Design Induction and follow-up of endometriosis in baboons, which is one of the primate species that develop spontaneous endometriosis. Forty-one baboons were checked for the presence of spontaneous endometriosis. We then attempted to induce endometriosis in 30 of them by endocervical canal resection. Setting Institute of Primate Research, Nairobi, Kenya, and Catholic University of Louvain, Brussels, Belgium. Animal(s) Forty-one baboons were checked for spontaneous endometriosis and 30 of them were used to develop a model of induced endometriosis. Intervention(s) A total of 41 baboons underwent diagnostic laparoscopy for 10 months. In a first step, 30 of this number subsequently underwent endocervical canal resection. In a second step, 20 of the 30 underwent uterine horn resection. Main Outcome Measure(s) Follow-up by laparoscopy. Result(s) Two of the 41 baboons were diagnosed with spontaneous endometriosis (4.8%). Twelve months after the surgical procedure to induce endometriosis, 8 of 29 animals presented with endometriotic lesions diagnosed by using laparoscopy and confirmed by histologic examination. The incidence of induced endometriosis in our model was thus 27.6%. In 2 baboons, endometriosis disappeared over time, resulting in a final rate of 20.7% (6/29). Conclusion(s) The rate of spontaneous endometriosis is very low (4.8%). Endometriosis can be induced (with a rate of just 27.6%) by endocervical canal resection to stimulate retrograde menstruation.