Meta-analysis of the radiological and clinical features of Usual Interstitial Pneumonia (UIP) and Nonspecific Interstitial Pneumonia (NSIP)

• Published in: PloS one Vol. 15; no. 1; p. e0226084
• Main Authors: Ebner, Lukas, Christodoulidis, Stergios, Stathopoulou, Thomai, Geiser, Thomas, Stalder, Odile, Limacher, Andreas, Heverhagen, Johannes T, Mougiakakou, Stavroula G, Christe, Andreas
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01-01-2020; Public Library of Science (PLoS)
• Subjects: Age Factors; Binary data; Biology and Life Sciences; Biomedical engineering; Biopsy; Computed tomography; Demographics; Demography; Diagnosis; Engineering research; Geriatrics; Hospitals; Humans; Idiopathic Pulmonary Fibrosis - diagnostic imaging; Idiopathic Pulmonary Fibrosis - epidemiology; Idiopathic Pulmonary Fibrosis - pathology; Lung - diagnostic imaging; Lung - physiology; Lung diseases; Lung Diseases, Interstitial - diagnostic imaging; Lung Diseases, Interstitial - epidemiology; Lung Diseases, Interstitial - pathology; Males; Medical diagnosis; Medical prognosis; Medicine and Health Sciences; Meta-analysis; Patients; Pediatrics; People and Places; Physical Sciences; Pneumonia; Prevalence; Preventive medicine; Pulmonary fibrosis; Radiology; Research and Analysis Methods; Sex Factors; Smoking; Social Sciences; Society; Systematic review; Tomography, X-Ray Computed; United States > US; Switzerland; Europe
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0226084

To conduct a meta-analysis to determine specific computed tomography (CT) patterns and clinical features that discriminate between nonspecific interstitial pneumonia (NSIP) and usual interstitial pneumonia (UIP).
The PubMed/Medline and Embase databases were searched for studies describing the radiological patterns of UIP and NSIP in chest CT images. Only studies involving histologically confirmed diagnoses and a consensus diagnosis by an interstitial lung disease (ILD) board were included in this analysis. The radiological patterns and patient demographics were extracted from suitable articles. We used random-effects meta-analysis by DerSimonian & Laird and calculated pooled odds ratios for binary data and pooled mean differences for continuous data.
Of the 794 search results, 33 articles describing 2,318 patients met the inclusion criteria. Twelve of these studies included both NSIP (338 patients) and UIP (447 patients). NSIP-patients were significantly younger (NSIP: median age 54.8 years, UIP: 59.7 years; mean difference (MD) -4.4; p = 0.001; 95% CI: -6.97 to -1.77), less often male (NSIP: median 52.8%, UIP: 73.6%; pooled odds ratio (OR) 0.32; p<0.001; 95% CI: 0.17 to 0.60), and less often smokers (NSIP: median 55.1%, UIP: 73.9%; OR 0.42; p = 0.005; 95% CI: 0.23 to 0.77) than patients with UIP. The CT findings from patients with NSIP revealed significantly lower levels of the honeycombing pattern (NSIP: median 28.9%, UIP: 73.4%; OR 0.07; p<0.001; 95% CI: 0.02 to 0.30) with less peripheral predominance (NSIP: median 41.8%, UIP: 83.3%; OR 0.21; p<0.001; 95% CI: 0.11 to 0.38) and more subpleural sparing (NSIP: median 40.7%, UIP: 4.3%; OR 16.3; p = 0.005; 95% CI: 2.28 to 117).
Honeycombing with a peripheral predominance was significantly associated with a diagnosis of UIP. The NSIP pattern showed more subpleural sparing. The UIP pattern was predominantly observed in elderly males with a history of smoking, whereas NSIP occurred in a younger patient population.