Pazopanib: Evidence review and clinical practice in the management of advanced renal cell carcinoma

• Published in: BMC pharmacology & toxicology Vol. 19; no. 1; p. 77
• Main Authors: Méndez-Vidal, María José, Molina, Áurea, Anido, Urbano, Chirivella, Isabel, Etxaniz, Olatz, Fernández-Parra, Eva, Guix, Marta, Hernández, Carolina, Lambea, Julio, Montesa, Álvaro, Pinto, Álvaro, Ros, Silverio, Gallardo, Enrique
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26-11-2018; BioMed Central; BMC
• Subjects: Angiogenesis; Antineoplastic agents; Binding sites; Cancer; Carcinoma, Renal cell; Cardiovascular diseases; Clinical medicine; Clinical trials; Dosage and administration; Drug therapy; Feasibility studies; Health services; Kidney cancer; Kidney neoplasms; Kinases; Medical research; Medicine; Meetings; Metastases; Metastasis; Patients; Pazopanib; Pharmacokinetics; Pharmacology; Practice; Protein kinase inhibitors; Quality of life; Questionnaires; Renal cell carcinoma; Renal failure; Safety; Targeted cancer therapy; Tumors; Vascular endothelial growth factor; Antineoplastic agents; Protein kinase inhibitors; Carcinoma, renal cell; Pazopanib; Kidney neoplasms; Quality of life
• ISSN: 2050-6511; 2050-6511
• DOI: 10.1186/s40360-018-0264-8

Pazopanib is indicated in the first-line treatment of metastatic renal cell cancer (mRCC). The aim of this study was to review the efficacy, safety, and pharmacokinetics of pazopanib and see how these aspects are linked to clinical practice.
A non-exhaustive systematic review was conducted according to the three topics. No publication restrictions were imposed and the selected languages were Spanish and English. After that, a summary of the main results and findings of the review was presented and discussed during three meetings (one for each topic) with 13 medical oncologists that usually treat mRCC. At these meetings, a questionnaire on the first-line use of pazopanib in clinical practice was also drawn up. After the meetings, the questionnaire was completed by 60 specialist medical oncologists in renal cancer.
The efficacy and safety of pazopanib have been demonstrated in several clinical trials, and subsequently confirmed in studies in real-world clinical practice. In addition to its clinical benefit and good safety profile, quality of life results for pazopanib, which compare favorably to sunitinib, make it a good option in the first-line treatment of patients. Special populations have been included in studies conducted with pazopanib, and it is safe for use in elderly patients, poor functional status, kidney failure, and mild or moderate hepatic impairment, and in patients with concomitant cardiovascular disease. The results of the questionnaire have shown that pazopanib is perceived as an effective drug, in which quality of life (QoL) outcomes are valued above all.
This paper offers a comprehensive and critical summary of efficacy, tolerability, and pharmacokinetics of pazopanib in the treatment of mRCC. Pazopanib is an effective treatment with an acceptable safety profile. Its QoL and tolerability results offer certain advantages when compared with other therapeutic alternatives, and its use appears to be safe in different patient profiles.