Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans

• Published in: Journal of lipid research Vol. 34; no. 3; pp. 343 - 358
• Main Authors: Kayden, HJ, Traber, MG
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01-03-1993; American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: absorcion digestiva; absorption digestive; Analytical, structural and metabolic biochemistry; antioxidantes; antioxidants; antioxydant; Biological and medical sciences; Biological Transport; blood circulation; blood plasma; carence en vitamine; circulacion sanguinea; circulation sanguine; Coenzymes, vitamins; deficiencia de vitaminas; digestive absorption; Fundamental and applied biological sciences. Psychology; Humans; Intestinal Absorption; lipoproteinas; lipoproteine; lipoproteins; Lipoproteins - metabolism; Malabsorption Syndromes - complications; metabolism; metabolisme; metabolismo; nutrientes; nutrients; Other biological molecules; plasma sanguin; plasma sanguineo; proteinas; proteine; proteins; substance nutritive; tocoferoles; tocopherol; tocopherols; vitamin deficiencies; Vitamin E - blood; Vitamin E - chemistry; Vitamin E - physiology; Vitamin E Deficiency - etiology; Vitamin E Deficiency - genetics; Human; α-Tocopherol; Lipoprotein; Biological transport; Blood plasma
• ISSN: 0022-2275; 1539-7262
• DOI: 10.1016/S0022-2275(20)40727-8

This review describes the general characteristics of vitamin E, then focuses on its absorption and transport in lipoproteins in normal subjects and in patients with either genetic abnormalities of lipoprotein metabolism or of vitamin E transport. The basis for the biological preference for RRR-alpha-tocopherol over other forms of vitamin E is then discussed. Finally, the evidence that the hepatic tocopherol-binding protein regulates vitamin E transport and plasma alpha-tocopherol concentrations is presented.