Evaluation of attenuation correction in cardiac PET using PET/MR

• Published in: Journal of nuclear cardiology Vol. 24; no. 3; pp. 839 - 846
• Main Authors: Lau, Jeffrey M.C., Laforest, R., Sotoudeh, H., Nie, X., Sharma, S., McConathy, J., Novak, E., Priatna, A., Gropler, R.J., Woodard, P.K.
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01-06-2017; Springer US; Springer Nature B.V
• Subjects: 18F-FDG; Attenuation correction; Cardiac; Cardiology; Dixon; Feasibility Studies; Female; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Imaging; Magnetic Resonance Imaging - instrumentation; Magnetic Resonance Imaging - methods; Male; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Myocardial Perfusion Imaging - instrumentation; Myocardial Perfusion Imaging - methods; Nuclear Medicine; Original Article; PET/MR; Phantoms, Imaging; Positron-Emission Tomography - instrumentation; Positron-Emission Tomography - methods; Radiology; Reproducibility of Results; Sensitivity and Specificity; Studies; Tomography; AC; PET/MR; SUV; Cardiac; PET/CT; MR-AC; CT-AC; 18F-FDG; LGE; Attenuation correction; Dixon; F-FDG
• ISSN: 1071-3581; 1532-6551
• DOI: 10.1007/s12350-015-0197-1

Simultaneous acquisition Positron emission tomography/magnetic resonance (PET/MR) is a new technology that has potential as a tool both in research and clinical diagnosis. However, cardiac PET acquisition has not yet been validated using MR imaging for attenuation correction (AC). The goal of this study is to evaluate the feasibility of PET imaging using a standard 2-point Dixon volume interpolated breathhold examination (VIBE) MR sequence for AC.
Evaluation was performed in both phantom and patient data. A chest phantom containing heart, lungs, and a lesion insert was scanned by both PET/MR and PET/CT. In addition, 30 patients underwent whole-body 18F-fluorodeoxyglucose PET/CT followed by simultaneous cardiac PET/MR. Phantom study showed 3% reduction of activity values in the myocardium due to the non-inclusion of the phased array coil in the AC. In patient scans, average standardized uptake values (SUVs) obtained by PET/CT and PET/MR showed no significant difference (n = 30, 4.6 ± 3.5 vs 4.7 ± 2.8, P = 0.47). There was excellent per patient correlation between the values acquired by PET/CT and PET/MR (R2 = 0.97).
Myocardial SUVs PET imaging using MR for AC shows excellent correlation with myocardial SUVs obtained by standard PET/CT imaging. The 2-point Dixon VIBE MR technique can be used for AC in simultaneous PET/MR data acquisition.