Emerging microfluidic devices for cancer cells/biomarkers manipulation and detection

Circulating tumour cells (CTCs) are active participants in the metastasis process and account for ∼90% of all cancer deaths. As CTCs are admixed with a very large amount of erythrocytes, leukocytes, and platelets in blood, CTCs are very rare, making their isolation, capture, and detection a major te...

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Bibliographic Details
Published in:	IET nanobiotechnology Vol. 10; no. 5; pp. 263 - 275
Main Authors:	Perez-Gonzalez, Victor Hugo, Gallo-Villanueva, Roberto Carlos, Camacho-Leon, Sergio, Gomez-Quiñones, Jose Isabel, Rodriguez-Delgado, Jose Manuel, Martinez-Chapa, Sergio Omar
Format:	Journal Article
Language:	English
Published:	England The Institution of Engineering and Technology 01-10-2016
Subjects:	Biomarkers biomedical equipment bioMEMS Blood blood samples Cancer cancer biomarker‐proteins cancer cell‐biomarker detection cancer cell‐biomarker manipulation cancer deaths cellular biophysics circulating tumour cells CTC detection Devices dielectrophoresis‐based devices electrophoresis Erythrocytes immunomagnetic‐affinity‐based devices leukocytes metastasis process microfluidic devices microfluidic technology Microfluidics molecular biophysics patient diagnosis platelets proteins quantum dots quantum‐dot‐based sensors Review Review Article Screening Sensors surface plasmon resonance surface‐plasmon‐resonance microfluidic sensors tumours cellular biophysics microfluidic devices biomedical equipment blood samples bioMEMS circulating tumour cells cancer biomarker-proteins cancer deaths electrophoresis quantum-dot-based sensors CTC detection erythrocytes surface plasmon resonance cancer cell-biomarker manipulation proteins microfluidic technology leukocytes tumours surface-plasmon-resonance microfluidic sensors cancer cell-biomarker detection immunomagnetic-affinity-based devices metastasis process platelets quantum dots dielectrophoresis-based devices cancer molecular biophysics microfluidics patient diagnosis
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Summary:	Circulating tumour cells (CTCs) are active participants in the metastasis process and account for ∼90% of all cancer deaths. As CTCs are admixed with a very large amount of erythrocytes, leukocytes, and platelets in blood, CTCs are very rare, making their isolation, capture, and detection a major technological challenge. Microfluidic technologies have opened-up new opportunities for the screening of blood samples and the detection of CTCs or other important cancer biomarker-proteins. In this study, the authors have reviewed the most recent developments in microfluidic devices for cells/biomarkers manipulation and detection, focusing their attention on immunomagnetic-affinity-based devices, dielectrophoresis-based devices, surface-plasmon-resonance microfluidic sensors, and quantum-dots-based sensors.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1751-8741 1751-875X 1751-875X
DOI:	10.1049/iet-nbt.2015.0060