Sleep deprivation and hippocampal vulnerability: changes in neuronal plasticity, neurogenesis and cognitive function

• Published in: Neuroscience Vol. 309; pp. 173 - 190
• Main Authors: Kreutzmann, J.C, Havekes, R, Abel, T, Meerlo, P
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 19-11-2015
• Subjects: adult neurogenesis; Animals; cognition; Cognition Disorders - pathology; Cognition Disorders - physiopathology; hippocampus; Hippocampus - pathology; Hippocampus - physiopathology; Humans; Learning - physiology; memory; Memory - physiology; Neurogenesis - physiology; Neurology; neuronal plasticity; Neuronal Plasticity - physiology; Sleep - physiology; sleep deprivation; Sleep Deprivation - pathology; Sleep Deprivation - physiopathology; AMPA; DG; memory; CPT; N-methyl- d-aspartate; NREM; 8-cyclopentyl-1,3-dimethylxanthine; LTP; 5-bromo-2′-deoxyuridine; cAMP; rapid eye movement; SD; mammalian target of rapamycin; CREB; phosphodiesterase 4; non-rapid eye movement; mTOR; NMDA; activity-regulated cytoskeleton-associated protein; brain-derived neurotrophic factor; protein kinase A; cAMP response element binding protein; adult neurogenesis; hippocampus; cognition; BDNF; EEG; long-term depression; PDE4; PKA; electroencephalogram; neuronal plasticity; fMRI; dentate gyrus; sleep deprivation; Arc; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; cyclic adenosine monophosphate; REM; LTD; BrdU; functional magnetic resonance imaging; long-term potentiation
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.04.053

Highlights • Sleep benefits neuronal plasticity and thereby supports brain function and cognition. • Sleep deprivation impairs hippocampus-dependent learning and memory. • Sleep deprivation impairs hippocampal cAMP-PKA signaling and gene transcription. • Sleep deprivation reduces hippocampal neurogenesis and hippocampal volume. • Chronic sleep disruption contributes to cognitive disorders and psychiatric diseases.