Low-intensity repetitive magnetic stimulation lowers action potential threshold and increases spike firing in layer 5 pyramidal neurons in vitro

Highlights • The acute effect of LI-rMS on layer 5 pyramidal neurons was investigated in vitro. • LI-rMS does not alter passive membrane properties. • LI-rMS induced hyperpolarized action potential thresholds. • LI-rMS Increased evoked spike firing frequency.

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Bibliographic Details
Published in:	Neuroscience Vol. 335; pp. 64 - 71
Main Authors:	Tang, Alexander D, Hong, Ivan, Boddington, Laura J, Garrett, Andrew R, Etherington, Sarah, Reynolds, John N.J, Rodger, Jennifer
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 29-10-2016
Subjects:	action potential threshold Action Potentials - physiology Animals Intermittent Theta Burst Stimulation low-intensity rMS Membrane Potentials - physiology Mice, Inbred C57BL Neurology Neuronal Plasticity - physiology Patch-Clamp Techniques - methods Pyramidal Cells - physiology spike firing frequency Transcranial Magnetic Stimulation - methods LI-rMS resting membrane potential AHP ACSF low-intensity rMS action potential threshold action potential artificial cerebrospinal fluid after hyperpolarization AP spike firing frequency low-intensity repetitive magnetic stimulation Intermittent Theta Burst Stimulation RMP rTMS repetitive transcranial magnetic stimulation
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Summary:	Highlights • The acute effect of LI-rMS on layer 5 pyramidal neurons was investigated in vitro. • LI-rMS does not alter passive membrane properties. • LI-rMS induced hyperpolarized action potential thresholds. • LI-rMS Increased evoked spike firing frequency.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.08.030