Transcriptome Analysis of Monozygotic Twin Brothers with Childhood Primary Myelofibrosis

• Published in: Genomics, proteomics & bioinformatics Vol. 15; no. 1; pp. 37 - 48
• Main Authors: Ding, Nan, Zhang, Zhaojun, Yang, Wenyu, Ren, Lan, Zhang, Yingchi, Zhang, Jingliao, Li, Zhanqi, Zhang, Peihong, Zhu, Xiaofan, Chen, Xiaojuan, Fang, Xiangdong
• Format: Journal Article
• Language: English
• Published: China Elsevier Ltd 01-02-2017; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100190, China%State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin 300020, China; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China%CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; Elsevier; Oxford University Press
• Subjects: Androgens - therapeutic use; Apoptosis; Bone Marrow - pathology; Child, Preschool; Childhood; Chromosomes, Human, Pair 19; Cytogenetic Analysis; Gene Expression Profiling; Gene Fusion; Hematological disease; Humans; Immunoglobulin lambda-Chains - genetics; Male; Monozygotic twin; Mutation, Missense; Original Research; Phosphoproteins - genetics; Prednisone - therapeutic use; Primary myelofibrosis; Primary Myelofibrosis - drug therapy; Primary Myelofibrosis - genetics; Primary Myelofibrosis - pathology; RNA - chemistry; RNA - isolation & purification; RNA - metabolism; RNA Splicing Factors - genetics; RNA-seq; Sequence Analysis, RNA; Serine-Arginine Splicing Factors - genetics; Twins, Monozygotic; Hematological disease; Primary myelofibrosis; RNA-seq; Monozygotic twin; Childhood; Apoptosis
• ISSN: 1672-0229; 2210-3244
• DOI: 10.1016/j.gpb.2016.12.002

Primary myelofibrosis （PMF） is a chronic myeloproliferative disorder in human bone marrow. Over 50% of patients with myelofibrosis have mutations in JAK2, MPL, or CALR. However, these mutations are rarely detected in children, suggesting a difference in the pathogenesis of childhood PMF. In this study, we investigated the response to drug treatment of a monozygotic twin pair with typical childhood PMF. The twin exhibited different clinical outcomes despite following