Osteolytic lesions, cytogenetic features and bone marrow levels of cytokines and chemokines in multiple myeloma patients: Role of chemokine (C-C motif) ligand 20

• Published in: Leukemia Vol. 30; no. 2; pp. 409 - 416
• Main Authors: Palma, B Dalla, Guasco, D, Pedrazzoni, M, Bolzoni, M, Accardi, F, Costa, F, Sammarelli, G, Craviotto, L, De Filippo, M, Ruffini, L, Omedè, P, Ria, R, Aversa, F, Giuliani, N
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-02-2016; Nature Publishing Group
• Subjects: 631/250/127/98; 631/250/1620/1342; 692/308/575; 692/699/1541/1990/804; 692/699/1670/1669; Activin; Aged; Benign monoclonal gammopathy; Biomedical materials; Bone diseases; Bone imaging; Bone marrow; Bone Marrow - immunology; Cancer Research; Care and treatment; CCL20 protein; CCL3 protein; Chemokine CCL20 - physiology; Chemokine CCL3 - analysis; Chemokines; Chemokines - analysis; Chromosome Aberrations; Computed tomography; Critical Care Medicine; Cytogenetics; Cytokines; Cytokines - analysis; Development and progression; Dkk1 protein; Female; Gene expression; Genetic aspects; Health aspects; Hematology; Humans; Intensive; Intercellular Signaling Peptides and Proteins - analysis; Internal Medicine; Lesions; Ligands; Magnetic Resonance Imaging; Male; Measurement; Medical examination; Medicine; Medicine & Public Health; Middle Aged; Multiple myeloma; Multiple Myeloma - complications; Multiple Myeloma - genetics; Multiple Myeloma - immunology; Oncology; original-article; Osteolysis; Osteolysis - etiology; Osteoprotegerin - analysis; Positron emission; Positron emission tomography; RANK Ligand - analysis; Smoldering; Surveys; Tomography; X-rays; Italy
• ISSN: 0887-6924; 1476-5551
• DOI: 10.1038/leu.2015.259

The relationship between bone marrow (BM) cytokine and chemokine levels, cytogenetic profiles and skeletal involvement in multiple myeloma (MM) patients is not yet defined. This study investigated a cohort of 455 patients including monoclonal gammopathy of uncertain significance (MGUS), smoldering MM and symptomatic MM patients. Skeletal surveys, positron emission tomography (PET)/computerized tomography (CT) and magnetic resonance imaging (MRI) were used to identify myeloma bone disease. Significantly higher median BM levels of both C-C motif Ligand (CCL)3 and CCL20 were found in MM patients with radiographic evidence of osteolytic lesions as compared with those without, and in all MM patients with positive PET/CT scans. BM levels of CCL3, CCL20, Activin-A and Dickkopf-1 (DKK-1) were significantly higher in patients with high bone disease as compared with patients with low bone disease. Moreover, CCL20 BM levels were significant predictors of osteolysis on X-rays by multivariate logistic analysis. On the other hand, DKK-1 levels were related to the presence of MRI lesions independently of the osteolysis at the X-rays. Our data define the relationship between bone disease and the BM cytokine and chemokine patterns highlighting the tight relationship between CCL20 BM levels and osteolysis in MM.