Systemic administration of resveratrol suppress the nociceptive neuronal activity of spinal trigeminal nucleus caudalis in rats

• Published in: Brain research bulletin Vol. 120; pp. 117 - 122
• Main Authors: Takehana, Shiori, Sekiguchi, Kenta, Inoue, Maki, Kubota, Yoshiko, Ito, Yukihiko, Yui, Kei, Shimazu, Yoshihito, Takeda, Mamoru
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-01-2016
• Subjects: Action Potentials - drug effects; Action Potentials - physiology; Administration, Intravenous; Alternative medicine; Analgesics - administration & dosage; Animals; Dose-Response Relationship, Drug; Face - physiology; Male; Microelectrodes; Neurology; Neurons - drug effects; Neurons - physiology; Nociception; Nociception - drug effects; Nociception - physiology; Physical Stimulation; Polyphenol; Rats, Wistar; Resveratrol; Single unit recording; Spinal trigeminal nucleus caudalis; Stilbenes - administration & dosage; Touch - drug effects; Touch - physiology; Trigeminal Caudal Nucleus - drug effects; Trigeminal Caudal Nucleus - physiopathology; Vitaceae; Nociception; WDR; TRPA1; 5-HT 3 receptor; trigeminal spinal nucleus caudalis; Spinal trigeminal nucleus caudalis; SpVc; CAM; transient receptor potential; Polyphenol; TRP; analysis of variance; ANOVA; 5-hydroxytrypytamine type 3 receptor; Alternative medicine; dorsal root ganglion; PAG; Resveratrol; TRP ankyrin 1; DRG; wide dynamic range; complementary and alternative medicine; periaqueductal gray; Single unit recording; 5-HT3 receptor
• ISSN: 0361-9230; 1873-2747
• DOI: 10.1016/j.brainresbull.2015.11.011

Highlights • Intravenous resveratrol administration suppress trigeminal WDR neuronal excitability. • Suppressive effect of resveratrol was dose-dependent and reversible manner. • Magnitude of inhibition was significantly greater for noxious than non-noxious stimulation. • Resveratrol contributes to CAM therapeutic agents for trigeminal nociception without side effect.