Effects of capsinoid on serum and liver lipids in hyperlipidemic rats

• Published in: Journal of Nutritional Science and Vitaminology Vol. 50; no. 5; pp. 351 - 355
• Main Authors: Tani, Y. (Nagoya Women's Univ. (Japan)), Fujioka, T, Sumioka, M, Furuichi, Y, Hamada, H, Watanabe, T
• Format: Journal Article
• Language: English
• Published: Tokyo Center for Academic Publications Japan 2004
• Subjects: Adipose Tissue - anatomy & histology; Adipose Tissue - enzymology; Animals; Biological and medical sciences; BLOOD SERUM; CAPSAICIN; Capsaicin - analogs & derivatives; Capsaicin - pharmacology; capsinoid; CHOLESTEROL; Dietary Fats - administration & dosage; Disorders of blood lipids. Hyperlipoproteinemia; Fatty Acid Synthases - metabolism; Hyperlipidemias - drug therapy; Hyperlipidemias - metabolism; Lipase - metabolism; LIPIDS; Lipids - analysis; Lipids - blood; LIPOPROTEIN LIPASE; Lipoprotein Lipase - genetics; Lipoprotein Lipase - metabolism; LIVER; Liver - chemistry; Liver - enzymology; liver lipid; Male; Medical sciences; Metabolic diseases; Organ Size; Rats; Rats, Wistar; RNA, Messenger - analysis; serum lipid; Weight Gain; Animal model; Rat; Digestive system; Enzyme; Liver; Rodentia; Metabolic diseases; Lipids; Esterases; Lipoprotein lipase; Cholesterol; Carboxylic ester hydrolases; Vertebrata; Mammalia; liver lipid; Animal; serum lipid; Hydrolases; Serum; Hyperlipemia; Dyslipemia; capsinoid
• ISSN: 0301-4800; 1881-7742
• DOI: 10.3177/jnsv.50.351

We compared the effects of capsinoid, a non-pungent component, on serum and liver lipids, with that of synthetic capsaicin in hyperlipidemic rats. Male Wistar rats of 9 wk old were divided into 4 groups: a control group receiving a high-fat diet containing 1% cholesterol, and capsaicin. capsinoid-I and capsinoid-II groups supplemented with 0.1 mmol of N-pelargonylvanillylamide (synthetic capsaicin), and 0.1 mmol and 1.0 mmol of capsinoid (capsiate : dihydrocapsiate=63: 37) per kg of control diet, respectively. All groups were pair-fed for 4 wk. Compared with the control group, serum lipid levels in both capsinoid groups and liver lipid contents in the capsinoid-II group showed the same reduction as that of the capsaicin group. In the capsaicin and capsinoid-I groups, fatty acid synthase (FAS) activities were lower and hepatic triacylglycerol lipase (HTGL) [EC 3.1.1.3] activities tended to be higher than those of control group. Lipoprotein lipase (LPL) [EC 3.1.1.34] activity in adipose tissue was higher in the capsaicin and capsinoid-II groups than in the control group. These results showed that capsinoid can improve serum and liver lipid metabolism comparable to synthetic capsaicin.