Factors predicting outcomes of penile rehabilitation with udenafil 50 mg following radical prostatectomy

• Published in: International journal of impotence research Vol. 28; no. 1; pp. 25 - 30
• Main Authors: Kim, T-H, Ha, Y-S, Choi, S H, Yoo, E S, Kim, B W, Yun, S-J, Kim, W-J, Kwon, Y S, Kwon, T G
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-01-2016; Nature Publishing Group
• Subjects: 59/57; 692/499; 692/699/2768/1575; Aged; Biopsy; Care and treatment; Complications and side effects; Drug therapy; Enzyme inhibitors; Erectile dysfunction; Erectile Dysfunction - drug therapy; Erectile Dysfunction - etiology; Erectile Dysfunction - physiopathology; Erectile Dysfunction - rehabilitation; Health aspects; Humans; Impotence; Male; Medicine; Medicine & Public Health; Middle Aged; original-article; Patients; Penis; Pharmaceutical industry; Phosphodiesterase 5 Inhibitors - administration & dosage; Postoperative Complications - drug therapy; Postoperative Complications - physiopathology; Postoperative Complications - rehabilitation; Prognosis; Prostate cancer; Prostatectomy; Prostatectomy - adverse effects; Prostatectomy - methods; Prostatic Neoplasms - surgery; Pyrimidines - administration & dosage; Recovery of Function - drug effects; Recovery of Function - physiology; Rehabilitation; Reproductive Medicine; Republic of Korea; Review boards; Risk Factors; rology; Sexual disorders; Sulfonamides - administration & dosage; Surgery; Treatment Outcome; Urological surgery; Urology; South Korea
• ISSN: 0955-9930; 1476-5489
• DOI: 10.1038/ijir.2015.28

Udenafil is a selective phosphodiesterase type 5 inhibitor made available in recent years for the treatment of erectile dysfunction. Herein, we evaluated independent predictors of potency recovery in radical prostatectomy (RP) patients who underwent penile rehabilitation with udenafil 50 mg. One hundred and forty-three men who underwent RP were enrolled in a penile rehabilitation program using udenafil 50 mg every other day. The rate of regained potency in the study group was significantly higher compared with the recovery rate seen in patients who were not part of the penile rehabilitation program (41.3% vs 13.0%;
P
<0.001). On the multivariate Cox analyses, preoperative International Index of Erectile Function-5 scores (hazard ratio (HR), 1.049;
P
=0.040), alcohol consumption (HR, 2.043;
P
=0.020) and Gleason biopsy score (HR, 0.368;
P
=0.024) were independent preoperative predictors for potency recovery. Among post-RP variables, the use of robotic procedures (HR, 2.287;
P
=0.030) and pathologic stage (HR, 0.506;
P
=0.038) were significantly associated with potency recovery. This study identified predictive factors for the recovery of potency in patients undergoing penile rehabilitation with udenafil following RP. Our results could provide physicians with useful information for counseling RP patients and selecting optimal candidates for penile rehabilitation.