Cholesterol-Based Compounds: Recent Advances in Synthesis and Applications

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 1; p. 116
• Main Authors: Albuquerque, Hélio M T, Santos, Clementina M M, Silva, Artur M S
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29-12-2018; MDPI
• Subjects: Animals; Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antiinfectives and antibacterials; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antioxidants; Antioxidants - chemical synthesis; Antioxidants - chemistry; Antioxidants - pharmacology; bioactive compounds; Biodistribution; bioimaging; Cancer; Chemistry; Chemistry Techniques, Synthetic; Cholesterol; Cholesterol - analogs & derivatives; Cholesterol - chemical synthesis; Cholesterol - chemistry; Cholesterol - pharmacology; Crystals; Drug delivery; Drug Delivery Systems; Drug Development - methods; gelators; Humans; Ligands; Lipids; Liquid Crystals; Liver; Medical imaging; Membranes; Molecular Imaging - methods; Review; synthesis; synthesis; bioimaging; gelators; bioactive compounds; cholesterol; drug delivery; liquid crystals
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules24010116

This review reports on the latest developments (since 2014) in the chemistry of cholesterol and its applications in different research fields. These applications range from drug delivery or bioimaging applications to cholesterol-based liquid crystals and gelators. A brief overview of the most recent synthetic procedures to obtain new cholesterol derivatives is also provided, as well as the latest anticancer, antimicrobial, and antioxidant new cholesterol-based derivatives. This review discusses not only the synthetic details of the preparation of new cholesterol derivatives or conjugates, but also gives a short summary concerning the specific application of such compounds.