Electrical Stimulation of Human Mesenchymal Stem Cells on Conductive Nanofibers Enhances their Differentiation toward Osteogenic Outcomes

• Published in: Macromolecular rapid communications. Vol. 36; no. 21; pp. 1884 - 1890
• Main Authors: Hardy, John G., Villancio-Wolter, Maria K., Sukhavasi, Rushi C., Mouser, David J., Aguilar Jr, David, Geissler, Sydney A., Kaplan, David L., Schmidt, Christine E.
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01-11-2015; Wiley Subscription Services, Inc
• Subjects: Biocompatibility; Biomedical materials; bone; Bone marrow; Bones; conducting polymers; Differentiation; electrical stimulation; Electrically conductive; Human; Scaffolds; Skin & tissue grafts; Stem cells; tissue scaffolds; electrical stimulation; stem cells; bone; conducting polymers; tissue scaffolds
• ISSN: 1022-1336; 1521-3927
• DOI: 10.1002/marc.201500233

Tissue scaffolds allowing the behavior of the cells that reside within them to be controlled are of particular interest for tissue engineering. Herein, the preparation of conductive fiber–based bone tissue scaffolds (nonwoven mats of electrospun polycaprolactone with an interpenetrating network of polypyrrole and polystyrenesulfonate) is described that enable the electrical stimulation of human mesenchymal stem cells to enhance their differentiation toward osteogenic outcomes.
Stimuli‐responsive materials enabling the behavior of the cells that reside within them to be controlled are vital for the development of instructive tissue scaffolds for tissue engineering. Herein, the electrically conductive nanofibrous bone tissue scaffolds are described that enhance the differentiation of human mesenchymal stem cells toward osteogenic outcomes.