Maternal/neonatal vitamin D deficiency: a risk factor for bronchopulmonary dysplasia in preterms?

• Published in: Journal of perinatology Vol. 35; no. 10; pp. 813 - 817
• Main Authors: Çetinkaya, M, Çekmez, F, Erener-Ercan, T, Buyukkale, G, Demirhan, A, Aydemir, G, Aydin, F N
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01-10-2015; Nature Publishing Group
• Subjects: 692/699/1785; Adult; Bronchopulmonary dysplasia; Bronchopulmonary Dysplasia - diagnosis; Calciferol; Complications and side effects; Dysplasia; Echocardiography; Female; Gestation; Gestational Age; Health aspects; Humans; Infant; Infant Nutritional Physiological Phenomena; Infant, Extremely Premature - blood; Infant, Newborn; Infant, Very Low Birth Weight - blood; Infants; Intensive Care Units, Neonatal; Levels; Logistic Models; Lung diseases; Male; Maternal Nutritional Physiological Phenomena; Maternal-fetal exchange; Medicine; Medicine & Public Health; Neonates; Newborn babies; Odds Ratio; original-article; Pediatric Surgery; Pediatrics; Postpartum Period - blood; Prospective Studies; Regression analysis; Respiratory distress syndrome; Respiratory Distress Syndrome, Newborn - complications; Risk analysis; Risk Factors; Turkey; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D deficiency; Vitamin D Deficiency - diagnosis; Vitamin deficiency; Young Adult
• ISSN: 0743-8346; 1476-5543
• DOI: 10.1038/jp.2015.88

Objective:
The objective of this study was to investigate the possible association between maternal/neonatal 25-hydroxy vitamin D (25-OHD) levels and development of bronchopulmonary dysplasia.
Study Design:
One hundred and thirty-two preterm infants ⩽32 weeks of gestation who were diagnosed with respiratory distress syndrome were enrolled. 25-OHD levels were determined in maternal/neonatal blood samples that were obtained at the time of admission to the neonatal intensive care unit.
Result:
A total of 100 infants were included and 31 (31%) developed bronchopulmonary dysplasia (BPD). Both maternal and neonatal 25-OHD levels in the BPD group were significantly lower compared with those in the no-BPD group (
P
=0.0001). A positive correlation was detected between maternal and neonatal 25-OHD levels. All of the infants with BPD had a 25-OHD level <10 ng ml
−1
, which represented severe deficiency. Univariate logistic regression analysis revealed that maternal/neonatal vitamin D levels were a significant predictor of BPD (odds ratio (OR): 0.76 and 0.61, respectively,
P
<0.001).
Conclusion:
We demonstrated for the first time that lower maternal and neonatal vitamin 25-OHD levels were associated with BPD development in preterm infants. However, further studies with larger sample sizes are needed to delineate the possible link between vitamin D deficiency and BPD.